摘要
目的:观察岩盐气溶胶疗法治疗尘肺病患者的效果。方法:回顾性分析2023年2月至2024年2月该院收治的94例尘肺病患者的临床资料,按照治疗方式不同将其分为对照组与观察组各47例。对照组采取常规治疗,观察组在对照组基础上采取岩盐气溶胶疗法治疗。比较两组治疗前后肺功能指标[第1秒用力呼气容积占用力肺活量百分比(FEV_(1)/FVC)、肺活量、最大自主通气量(MVV)]、炎性因子[白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)]、血气分析指标[动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))]水平,以及不良反应发生率。结果:治疗4周后,两组FEV_(1)/FVC、肺活量、MVV水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗4周后,两组IL-6、IL-8、TNF-α水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗4周后,两组PaO_(2)水平均高于治疗前,且观察组高于对照组,两组PaCO_(2)水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:岩盐气溶胶疗法治疗尘肺病患者可提高肺功能指标水平,改善血气分析指标水平,以及降低炎性因子水平,效果优于单纯常规治疗。
Objective:To observe the effectiveness of rock salt aerosol therapy in treating patients with pneumoconiosis.Methods:The clinical data of 94 patients with pneumoconiosis admitted to this hospital from February 2023 to February 2024 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,47 cases in each group.The control group was treated with conventional treatment,while the observation group was treated with rock salt aerosol therapy on the basis of that of the control group.The levels of lung function indexes[forced expiratory volume in one second to forced vital capacity(FEV_(1)/FVC),vital capacity,maximum voluntary ventilation(MVV)],inflammatory factors[interleukin-6(IL-6),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)]and blood gas analysis indexes[arterial partial pressure of oxygen(PaO_(2)),arterial partial pressure of carbon dioxide(PaCO_(2))]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:After 4 weeks of treatment,the levels of FEV_(1)/FVC,vital capacity and MVV in the two groups were higher than those before the treatment,those in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).After 4 weeks of treatment,the levels of IL-6,IL-8 and TNF-αin the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After 4 weeks of treatment,the PaO_(2)levels of the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;the PaCO_(2)levels of the two groups were lower than those before the treatment,and that in the observation group was lower than that in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Rock salt aerosol therapy can improve lung function indicators,improve blood gas analysis indicators,and reduce inflammatory factor levels in patients with pneumoconiosis,and the effect is better than conventional treatment alone.
作者
张蕊
ZHANG Rui(1^(st)Department of Occupational Disease of General Hospital of Zhengzhou Coal Industry(Group)Co.,Ltd.,Zhengzhou 452370 Henan,China)
出处
《中国民康医学》
2025年第11期40-42,46,共4页
Medical Journal of Chinese People’s Health
关键词
尘肺病
岩盐气溶胶疗法
肺功能
血气分析指标
炎性因子
不良反应
Pneumoconiosis
Rock salt aerosol therapy
Lung function
Blood gas analysis index
Inflammatory factor
Adverse reaction
