摘要
目的分析小儿肺炎支原体肺炎早期诊断中行血清肺炎支原体抗体、总免疫球蛋白E(IgE)检验的临床价值。方法选择120例肺炎支原体肺炎患儿为试验组,同期120例无呼吸道感染的健康儿童为对照组。两组儿童均开展肺炎支原体抗体与总IgE检验。比较两组肺炎支原体抗体阳性检出率,对照组与试验组不同支原体抗体滴度的血清总IgE水平及阳性检出率,血清肺炎支原体抗体、总IgE单独及联合检验对小儿肺炎支原体肺炎的诊断效能;分析血清肺炎支原体抗体、总IgE单独及联合检验结果与金标准的一致性。结果试验组肺炎支原体抗体阳性检出率83.33%(100/120)较对照组的25.00%(30/120)高(P<0.05)。试验组阴性、低滴度、高滴度血清总IgE阳性检出率分别为50.00%、86.79%、97.87%,均高于对照组的20.83%(P<0.05);试验组低滴度、高滴度的血清总IgE阳性检出率高于阴性,高滴度高于低滴度(P<0.05)。试验组阴性、低滴度、高滴度血清总IgE水平均高于对照组(P<0.05);试验组低滴度、高滴度的血清总IgE水平高于阴性,高滴度高于低滴度(P<0.05)。联合检验的诊断敏感度、特异度较单独血清肺炎支原体抗体、总IgE检验高(P<0.05);以金标准诊断结果为基准,联合检验结果的一致性(Kappa值=0.826)较肺炎支原体抗体、总IgE单独检验高。结论在小儿肺炎支原体肺炎早期诊断中采用血清肺炎支原体抗体、总IgE联合检验的临床价值显著,可有效提高疾病诊断效能。
Objective To analyze the clinical value of serum Mycoplasma pneumoniae antibody and total immunoglobulin E(IgE)test in early diagnosis of Mycoplasma pneumoniae pneumonia in children.Methods 120 children with Mycoplasma pneumoniae pneumonia were selected as the experimental group,and 120 healthy children without respiratory infections during the same period were included as the control group.Mycoplasma pneumoniae antibody and total IgE tests were conducted for both groups.Comparison of the positive detection rate of Mycoplasma pneumoniae antibody between the two groups,the serum total IgE level and positive detection rate of children with different Mycoplasma antibody titers in the experimental group and the control group,and the diagnostic efficacy of serum Mycoplasma pneumoniae antibody,total IgE alone and in combination for Mycoplasma pneumoniae pneumonia in children;analysis of the consistency of results of serum Mycoplasma pneumoniae antibody,total IgE alone and in combination with the gold standard.Results The positive detection rate of Mycoplasma pneumoniae antibody was 83.33%(100/120)in the experimental group,which was higher than 25.00%(30/120)in the control group(P<0.05).The positive detection rates of serum total IgE in negative,low-titer,and high-titer children in the experimental group were 50.00%,86.79%,and 97.87%,which were higher than 20.83%in the control group(P<0.05).In the experimental group,the positive detection rate of total serum IgE in low-titer and high-titer children was higher than that of negative children,and high-titer children was higher than low-titer children(P<0.05).The diagnostic sensitivity and specificity of the combined test were higher than that of serum Mycoplasma pneumoniae antibody and total IgE test alone(P<0.05).Based on the gold standard,the consistency of combined test(Kappa value=0.826)was higher than that of Mycoplasma pneumoniae antibody and total IgE alone.Conclusion Combined test of serum Mycoplasma pneumoniae antibody and total IgE has significant clinical value for children with Mycoplasma pneumoniae pneumonia,and can effectively improve the diagnosis efficiency of the disease.
作者
袁媛
夏存华
YUAN Yuan;XIA Cun-hua(Laboratory Department,Liaocheng Traditional Chinese Medicine Hospital,Liaocheng 252000,China)
出处
《中国现代药物应用》
2025年第11期84-87,共4页
Chinese Journal of Modern Drug Application
关键词
小儿肺炎支原体肺炎
早期诊断
血清肺炎支原体抗体
总免疫球蛋白E检验
敏感度
特异度
Mycoplasma pneumoniae pneumonia in children
Early diagnosis
Serum Mycoplasma pneumoniae antibody
Total immunoglobulin E test
Sensitivity
Specificity
