摘要
目的探讨2型糖尿病、糖尿病肾病对牙种植修复患者术后牙周健康的影响。方法整理种植科接受牙种植修复患者的临床资料,选取其中30例合并2型糖尿病患者作为糖尿病组,30例合并糖尿病肾病患者作为糖尿病肾病组,30例无其他急慢性疾病患者作为对照组。所有患者均接受下颌后牙区单颗常规种植修复治疗。比较三组患者术后种植体周围炎与牙槽骨丧失发生情况,龈沟出血指数(SBI)、牙周探诊深度(PD)、菌斑指数(PLI)及龈沟液炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)]水平。结果对照组种植体周围炎、牙槽骨丧失发生率分别为3.33%、6.67%,均低于糖尿病组的20.00%、26.67%和糖尿病肾病组的33.33%、36.67%,统计学结果有显著差异(P<0.05);糖尿病组种植体周围炎、牙槽骨丧失发生率略低于糖尿病肾病组,但无统计学差异(P>0.05)。对照组术后SBI、PD、PLI水平分别为(1.25±0.21)分、(2.51±0.43)mm、(1.26±0.25)分,均低于糖尿病组的(1.78±0.34)分、(3.16±0.51)mm、(1.84±0.33)分和糖尿病肾病组的(2.24±0.48)分、(3.68±0.60)mm、(2.37±0.41)分,统计学结果有显著差异(P<0.05);糖尿病组术后SBI、PD、PLI水平均低于糖尿病肾病组,统计学结果有显著差异(P<0.05)。对照组术后龈沟液TNF-α、IL-6、IL-1β水平分别为(4.52±0.86)、(35.47±6.16)、(0.81±0.14)ng/L,均低于糖尿病组的(5.16±1.03)、(43.12±7.08)、(1.06±0.21)ng/L和糖尿病肾病组的(6.08±1.12)、(50.16±8.26)、(1.24±0.26)ng/L,统计学结果有显著差异(P<0.05);糖尿病组术后龈沟液TNF-α、IL-6、IL-1β水平均低于糖尿病肾病组,统计学结果有显著差异(P<0.05)。结论2型糖尿病与糖尿病肾病会影响牙种植修复患者术后牙周健康状况,增加种植体周围炎发生率,尤其是糖尿病肾病更为严重。
Objective To explore the effect of type 2 diabetes mellitus and diabetic nephropathy on periodontal health of patients with dental implant restoration.Methods The clinical data of patients who received dental implant restorations in the Department of Implantology were compiled.Among them,30 patients with type 2 diabetes mellitus were selected as the diabetes group,30 patients with diabetic nephropathy were selected as the diabetic nephropathy group,and 30 patients without any other acute or chronic diseases were selected as the control group.All patients were treated with single conventional implant restorations in the mandibular posterior region.Comparison was made on incidence of postoperative peri-implantitis and alveolar bone loss,sulcus bleeding index(SBI),periodontal probing depth(PD),plaque index(PLI),and inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and interleukin-1β(IL-1β)]in gingival sulcus fluid among the three groups.Results The incidence rates of peri-implantitis and alveolar bone loss in the control group were 3.33%and 6.67%,which were lower than 20.00%and 26.67%in the diabetes group,and 33.33%and 36.67%in the diabetic nephropathy group,and there were significant differences in statistical results(P<0.05).The incidence rates of peri-implantitis and alveolar bone loss in the diabetes group were slightly lower than that in the diabetic nephropathy group,but there were no significant differences in statistical results(P>0.05).The levels of SBI,PD and PLI in the control group were(1.25±0.21)points,(2.51±0.43)mm and(1.26±0.25)points,which were lower than(1.78±0.34)points,(3.16±0.51)mm and(1.84±0.33)points in diabetes group,and(2.24±0.48)points,(3.68±0.60)mm and(2.37±0.41)points in diabetic nephropathy group,and there were significant differences in statistical results(P<0.05).The levels of SBI,PD and PLI in the diabetes group were lower than those in the diabetic nephropathy group,and there were significant differences in statistical results(P<0.05).The levels of TNF-α,IL-6 and IL-1βin gingival creval fluid of the control group were(4.52±0.86),(35.47±6.16)and(0.81±0.14)ng/L,which were lower than(5.16±1.03),(43.12±7.08)and(1.06±0.21)ng/L of the diabetes group,and(6.08±1.12),(50.16±8.26)and(1.24±0.26)ng/L of the diabetic nephropathy group,and there were significant differences in statistical results(P<0.05).The levels of TNF-α,IL-6 and IL-1βin gingival creval fluid in the diabetes group were lower than those in diabetic nephropathy group,and there were significant differences in statistical results(P<0.05).Conclusion Type 2 diabetes mellitus and diabetic nephropathy can affect the periodontal health of patients with dental implant restoration and increase the incidence of peri-implantitis,which is especially severe in the case of diabetic nephropathy.
作者
刘薇薇
哈力代·东木拉提
李莎
童乔莹
杨玮哲
戴晓玮
LIU Wei-wei;Halidai Dongmulati;LI Sha(Department of Implantology,Urumqi Stomatological Hospital,Urumqi 830001,China)
出处
《中国现代药物应用》
2025年第11期71-74,共4页
Chinese Journal of Modern Drug Application
关键词
糖尿病肾病
牙种植修复
种植体周围炎
2型糖尿病
牙周健康
炎性因子
Diabetic nephropathy
Dental implant restoration
Peri-implantitis
Type 2 diabetes mellitus
Periodontal health
Inflammatory factor
