摘要
目的分析活血补肾中药方联合低剂量美金刚治疗脑卒中后认知功能障碍的效果。方法100例脑卒中后认知功能障碍患者,根据来院日期的单双号分为观察组和对照组,每组50例。观察组采用活血补肾中药方联合低剂量美金刚治疗,对照组采用低剂量美金刚治疗。比较两组临床效果及治疗前后的简易精神状态检查量表(MMSE)评分、蒙特利尔认知评估量表(MoCA)评分、脑血流速度、同型半胱氨酸(Hcy)、胱抑素C(Cys-C)水平。结果和对照组的(22.42±3.59)、(22.58±3.87)分相比,观察组患者治疗后的MMSE评分(26.89±4.23)分、MoCA评分(25.26±4.56)分均更高,体现明显差异(P<0.05)。和对照组的(38.19±4.22)、(25.26±2.43)cm/s相比,观察组患者治疗后的大脑后动脉血流速度(45.61±5.08)cm/s、脑部椎动脉血流速度(29.19±3.27)cm/s均更高,体现明显差异(P<0.05)。和对照组的(1.07±0.26)mg/L、(11.48±2.45)μmol/L相比,观察组患者治疗后的Cys-C(0.69±0.18)mg/L、Hcy(7.86±1.25)μmol/L均更低,体现明显差异(P<0.05)。和对照组的78.00%相比,观察组患者的总有效率94.00%更高,体现明显差异(P<0.05)。结论脑卒中后认知功能障碍采用活血补肾中药方联合低剂量美金刚治疗可以促进患者脑血流速度改善,提高智能和认知功能的恢复效果。
Objective To analyze the effect of kidney-tonifying and blood-activating Chinese herbs combined with low-dose memantine on post-stroke cognitive dysfunction.Methods 100 patients with post-stroke cognitive dysfunction were divided into an observation group and a control group according to the odd-even date of admission,with 50 cases in each group.The observation group was treated with kidney-tonifying and blood-activating Chinese herbs combined with low-dose memantine,and the control group was treated with low-dose memantine.Comparison of clinical effects and scores of mini-mental state examination(MMSE),Montreal Cognitive Assessment Scale(MoCA),cerebral blood flow velocity,homocysteine(Hcy)and cystatin C(Cys-C)before and after treatment between two groups.Results Compared with(22.42±3.59)and(22.58±3.87)points in the control group,MMSE score(26.89±4.23)points and MoCA score(25.26±4.56)points in the observation group were higher after treatment,showing significant differences(P<0.05).Compared with(38.19±4.22)and(25.26±2.43)cm/s in the control group,the posterior cerebral artery blood flow velocity(45.61±5.08)cm/s and the vertebral artery blood flow velocity(29.19±3.27)cm/s in the observation group after treatment were higher,showing significant differences(P<0.05).Compared with(1.07±0.26)mg/L and(11.48±2.45)μmol/L in the control group,Cys-C(0.69±0.18)mg/L and Hcy(7.86±1.25)μmol/L in the observation group after treatment were lower,showing significant differences(P<0.05).Compared with 78.00%in the control group,the total effective rate of the observation group was 94.00%,showing a significant difference(P<0.05).Conclusion The combination of kidney-tonifying and blood-activating Chinese herbs and low-dose memantine can promote the improvement of cerebral blood flow velocity and enhance the recovery of intelligence and cognitive function in patients with for post-stroke cognitive dysfunction.
作者
段晓丽
唐共霞
DUAN Xiao-li;TANG Gong-xia(Third Department of Encephalopathy,Jinan Hospital of Integrated Traditional Chinese and Western Medicine,Jinan 271100,China)
出处
《中国实用医药》
2025年第11期144-147,共4页
China Practical Medicine
基金
任绪东全国名老中医药专家传承工作室(项目编号:国中医药人教函(2022)75号)。
关键词
脑卒中
认知功能障碍
美金刚
活血补肾中药方
认知功能
Stroke
Cognitive dysfunction
Memantine
Kidney-tonifying and blood-activating Chinese herbs
Cognitive function
