摘要
在中国,超过4000万体型偏瘦或正常体重的个体正面临2型糖尿病(T2DM)的困扰。十二指肠黏膜重塑术(DMR)作为连接手术与药物治疗的桥梁,展现出在血糖控制和代谢改善方面的巨大潜力。文章旨在全面回顾DMR在调节肠源性激素、肠道菌群生态以及糖脂代谢中的作用,探讨其在优化肠道功能和改善代谢健康中的潜力。通过从肠源性激素对糖脂代谢的调控、肠道菌群稳态的变化以及DMR机制的探讨等多个角度进行分析,回顾现有的临床研究及团队掌握的动物实验数据。尽管DMR未直接调控肠源性激素的分泌,但它显著调节了肠道菌群的组成,并可能通过改善肠道菌群生态间接促进糖脂代谢的改善。然而,当前的临床研究仍面临样本量小、机制探讨不够深入等挑战。因此,未来的研究应通过更大规模的临床试验和动物模型验证DMR对肠道菌群和代谢健康的具体作用,为糖尿病治疗提供新的选择。
In China,over 40 million individuals with a lean or normal body type are facing the challenges of type 2 diabetes mellitus(T2DM).Duodenal mucosal resurfacing(DMR),as a bridge between surgical and pharmacological treatments,demonstrates significant potential in blood glucose control and metabolic improvement.This study aims to comprehensively review the role of DMR in regulating gut-derived hormones,gut microbiota ecology,and glucose-lipid metabolism,exploring its potential in optimizing gut function and improving metabolic health.By analyzing from multiple perspectives,including the regulation of glucose-lipid metabolism by gut-derived hormones,changes in gut microbiota homeostasis,and the mechanisms of DMR,this article reviews existing clinical studies and animal experimental data obtained by the research team.The findings indicate that although DMR does not directly regulate the secretion of gut-derived hormones,it significantly modulates the composition of gut microbiota and may indirectly promote the improvement of glucose-lipid metabolism through the enhancement of gut microbiota ecology.However,current clinical studies still face challenges such as small sample sizes and insufficient exploration of underlying mechanisms.Therefore,future research should validate the specific effects of DMR on gut microbiota and metabolic health through larger-scale clinical trials and animal models,providing new options for diabetes treatment.
作者
周博军
王思奇
李政奇
周彪
孟化
ZHOU Bo-jun;WANG Si-qi;LI Zheng-qi;ZHOU Biao;MENG Hua(Department of GeneralSurgery and Obesity and Metabolic Disease Center,China-Japan Friendship Hospital,Beijing 100029,China)
出处
《中国实用内科杂志》
北大核心
2025年第4期273-278,288,共7页
Chinese Journal of Practical Internal Medicine
基金
中日友好医院中央高水平医院临床科研业务费(2023-NHLHCRF-YYPP-TS-02,2023-NHLHCRF-YS-0103)
国家自然科学基金面上项目(82470857)
北京市自然科学基金面上项目(7242125)
北京市研究型病房建设临床研究项目(2022-YJXBF-03-02)。
关键词
2型糖尿病
十二指肠黏膜重塑术
肠源性激素
肠道菌群
糖脂代谢
type 2 diabetes
duodenal mucosal resurfacing
gut-derived hormones
gut microbiota
glucose and lipid metabolism
