摘要
目的探讨地尔硫䓬联合美托洛尔对冠心病不稳定型心绞痛患者的治疗效果。方法90例冠心病不稳定型心绞痛患者,按照双色小球法分为参照组和研究组,每组45例。参照组接受常规治疗加美托洛尔、硝酸异山梨酯片治疗,研究组在参照组治疗基础上加用地尔硫䓬治疗。对比两组患者心功能指标(左室射血分数、左室收缩末期内径、左室舒张末期内径)、心绞痛发生情况、血脂指标(甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇)、治疗效果。结果治疗后,研究组患者左室射血分数(56.4±3.1)%高于参照组的(50.6±2.8)%,左室收缩末期内径(38.7±2.6)mm、左室舒张末期内径(50.0±3.2)mm小于参照组的(41.5±2.9)、(54.7±4.0)mm(P<0.05)。治疗后,研究组心率(67.3±1.2)次/min、心绞痛发作次数(1.4±0.3)次/周均低于参照组的(74.1±2.6)次/min、(2.8±0.7)次/周,心绞痛持续时间(1.4±0.4)min/次短于参照组的(3.6±1.0)min/次(P<0.05)。治疗后,研究组患者甘油三酯(1.8±0.4)mmol/L、低密度脂蛋白胆固醇(1.7±0.5)mmol/L均低于参照组的(2.1±0.7)、(2.4±0.7)mmol/L,高密度脂蛋白胆固醇(1.8±0.3)mmol/L高于参照组的(1.3±0.2)mmol/L(P<0.05)。研究组的治疗总有效率97.78%高于参照组的80.00%(P<0.05)。结论通过地尔硫䓬联合美托洛尔对冠心病不稳定型心绞痛患者进行治疗,可以促使患者的病情改善,切实提高对心绞痛的控制效果,并能够显著增强患者的心功能;同时可以调节患者的血脂状态,改善患者的身体素质,从而取得理想的预后。
Objective To explore the effect of diltiazem combined with metoprolol in the treatment of patients with unstable angina pectoris of coronary heart disease and its influence on cardiac function.Methods 90 patients with unstable angina pectoris of coronary heart disease were divided into a reference group and a study group according to two-color ball method,with 45 cases in each group.The reference group received conventional treatment plus metoprolol and isosorbide dinitrate tablets,and the study group was treated with diltiazem on the basis of the reference group.Patients in both groups were compared in terms of cardiac function indexes(left ventricular ejection fraction,left ventricular end-systolic diameter,left ventricular end-diastolic diameter),incidence of angina pectoris,blood lipid indexes(triglyceride,high density lipoprotein cholesterol,low density lipoprotein cholesterol),and treatment effect.Results After treatment,the study group had a higher left ventricular ejection fraction of(56.4±3.1)%than(50.6±2.8)%in the reference group;in the study group,the left ventricular end-systolic diameter was(38.7±2.6)mm and the left ventricular end-diastolic diameter was(50.0±3.2)mm,which were smaller than(41.5±2.9)and(54.7±4.0)mm in the reference group(P<0.05).After treatment,the study group had heart rate of(67.3±1.2)beats/min and frequency of angina pectoris attacks of(1.4±0.3)times/week,which were lower than(74.1±2.6)times/min and(2.8±0.7)times/week in the reference group;the study group had duration of angina pectoris of(1.4±0.4)min/time,which was shorter than(3.6±1.0)min/time in the control group(P<0.05).After treatment,the triglyceride and low density lipoprotein cholesterol were(1.8±0.4)and(1.7±0.5)mmol/L in the study group,which were lower than(2.1±0.7)and(2.4±0.7)mmol/L in the reference group;the high density lipoprotein cholesterol in the study group was(1.8±0.3)mmol/L,which was higher than(1.3±0.2)mmol/L in the reference group(P<0.05).The total response rate of the study group was 97.78%,which was higher than 80.00%of the reference group(P<0.05).Conclusion Diltiazem combined with metoprolol in the treatment of patients with unstable angina pectoris of coronary heart disease can contribute to the improvement of the patient's condition,effectively improve the control of angina pectoris,and can significantly enhance the patient's cardiac function.At the same time,it can regulate the patient's blood lipid status,improve the patient's physical quality,and thus achieve an ideal prognosis.
作者
雷柯
LEI Ke(Emergency Department,Huaibei Traditional Chinese Medicine Hospital,Huaibei 235000,China)
出处
《中国现代药物应用》
2025年第10期21-25,共5页
Chinese Journal of Modern Drug Application
关键词
地尔硫䓬
美托洛尔
冠心病
不稳定型心绞痛
治疗效果
心功能
Diltiazem
Metoprolol
Coronary heart disease
Unstable angina pectoris
Therapeutic effect
Cardiac function
