摘要
目的探讨富马酸比索洛尔联合地尔硫卓在冠心病心绞痛(CAP)患者中的应用效果。方法选择该院2022年9月—2023年9月收治的84例CAP患者为研究对象,按随机数字表法将患者分为对照组和观察组,各42例。对照组采用富马酸比索洛尔治疗,观察组采用富马酸比索洛尔联合地尔硫卓治疗,两组均持续治疗3个月。对比两组的心绞痛发作情况、血管内皮功能、临床疗效、不良反应发生情况。结果与对照组相比,观察组心绞痛发作次数较少,疼痛视觉模拟评分较低,持续时间较短,组间差异有统计学意义(P<0.05)。治疗后,观察组一氧化氮水平高于对照组,内皮素、血管内皮生长因子水平均低于对照组,组间差异有统计学意义(P<0.05)。观察组治疗总有效率为4.76%,高于对照组的19.05%,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论富马酸比索洛尔联合地尔硫卓在CAP患者中具有较好的应用效果,有利于改善心绞痛发作情况,改善血管内皮功能,提升临床疗效,且不会增加不良反应的发生,应用安全性较好。
Objective To explore the application effect of bisoprolol fumarate combined with diltiazem in patients with coronary angina pectoris(CAP).Methods 84 CAP patients admitted to the hospital from September 2022 to September 2023 were selected as the research subjects.The patients were randomly divided into a control group and an observation group,with 42 cases in each group,using a random number table method.The control group was treated with bisoprolol fumarate,while the observation group was treated with bisoprolol fumarate combined with diltiazem,both groups were treated continuously for 3 months.Compare the incidence of angina pectoris,vascular endothelial function,clinical efficacy,and adverse reactions between two groups.Results Compared with the control group,the observation group had fewer episodes of angina,lower pain Visual Analogue Scale scores,shorter duration,and statistically significant differences between the groups(P<0.05).After treatment,the level of nitric oxide in the observation group was higher than that in the control group,while the levels of endothelin and vascular endothelial growth factor were lower than those in the control group.The differences between the groups were statistically significant(P<0.05).The total effective rate of the observation group was 4.76%,which was higher than the control group's 19.05%,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of bisoprolol fumarate and diltiazem has a good application effect in CAP patients,which is beneficial for improving angina attacks,improving endothelial function,enhancing clinical efficacy,and does not increase the occurrence of adverse reactions.The application is safe.
作者
仝艳琼
吴刚
TONG Yanqiong;WU Gang(Department of Cardiology,Hulunbuir People's Hospital,Hulunbuir Inner Mongolia,021000,China)
出处
《反射疗法与康复医学》
2024年第7期107-109,共3页
Reflexology And Rehabilitation Medicine
关键词
冠心病心绞痛
富马酸比索洛尔
地尔硫卓
心绞痛发作
血管内皮功能
临床疗效
Coronary angina pectoris
Bisoprolol fumarate
Diltiazem
An attack of angina pectoris
Vascular endothelial function
Clinical efficacy
