摘要
慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)作为一项全球性的健康挑战,对患者及其家庭带来了沉重的经济与心理负担。准确识别COPD的影响因素,同时排除虚假关联,对于理解其发病机制和制定预防策略至关重要。孟德尔随机化法(Mendelian randomization,MR)作为一种补充手段,以其独特的优势在减少混杂因素干扰、降低实验研究成本和规避实验伦理问题方面显示出巨大潜力。本文将围绕MR及其主要衍生方法,分别讨论了以上方法的基本原理和适用条件,并结合具体案例分析了它们在COPD研究中的应用效果和局限性,以期使MR在COPD影响因素研究中获得更广泛的应用。
Chronic obstructive pulmonary disease(COPD),as a global health challenge,brings heavy economic and psychological burdens to patients and their families.Accurately identifying the risk factors for COPD and excluding false associations are crucial for understanding its pathogenesis and formulating prevention strategies.Mendelian randomization(MR),as a supplementary method,has shown great potential in reducing the interference of confounding factors,lowering the cost of experimental research,and avoiding experimental ethical issues.This article focuses on MR and its main derivative methods,discusses their basic principles and applicable conditions,and analyzes their application effects and limitations in COPD research in combination with specific cases,enabling MR to be more widely applied in the study of influencing factors of COPD.
作者
田志军
申奥
李甜甜
李蕙杏
周宇丹
郭宏
TIAN Zhijun;SHEN Ao;LI Tiantian;LI Huixing;ZHOU Yudan;Guo Hong(School of Public Health,Shenyang Medical College,Shenyang 110034,China;School of Nursing,Shenyang Medical College,Shenyang 110034,China)
出处
《沈阳医学院学报》
2025年第3期304-309,327,共7页
Journal of Shenyang Medical College
基金
辽宁省社会科学规划基金(No.L21BBK005)
沈阳医学院科学研究基金(No.20201018)。
关键词
孟德尔随机化
孟德尔随机化衍生方法
慢性阻塞性肺疾病
影响因素
Mendelian randomization
Mendelian randomization derivative methods
chronic obstructive pulmonary disease
influencing factors
