摘要
多发性骨髓瘤(multiple myeloma,MM)的形成是一个涉及多种生物学因素和分子机制相互作用的复杂过程,与多种信号通路、肿瘤微环境(tumor micro-environment,TME)之间的相互作用密切相关。微小RNA(microRNA,miRNA)是一类高度稳定的小型非编码RNA,miR⁃28⁃3p作为其重要一员,通过诱导磷酸酶和张力蛋白同源基因(phosphatase and tensin homolog deleted on chromosome ten,PTEN)的表达及其他重要细胞因子的产生,在调控细胞增殖、凋亡、侵袭及转移等重要环节发挥其功能。本文结合国内外研究对miR⁃28⁃3p的作用机制进行综述,有助于阐明miR⁃28⁃3p在MM的发生、发展过程中发挥的重要作用及其分子机制,为其在MM的基因诊断、治疗靶标开发方面提供了新的理论依据和潜在靶点。
The formation of multiple myeloma is a complex process involving the interaction of multiple biological factors and molecular mechanisms,which is closely related to the interaction between multiple signaling pathways and tumor micro-environment(TME).MicroRNA(miRNA)is a highly stable class of small non-coding RNAs.As an important member,miR-28-3p shows its characteristics in multiple myeloma by inducing the production of PTEN gene and other important cytokines,and regulates cell proliferation,apoptosis,invasion and metastasis.This article reviews the mechanism of action of miR-28-3p based on domestic and foreign studies,which is helpful to elucidate the important role played by miR-28-3p in the emergence and gradual development of multiple myeloma and the molecular mechanism behind it,and provides a new theoretical basis and potential targets for the genetic diagnosis and therapeutic target development of multiple myeloma.
作者
贾怡婷
李光耀
张丽
JIA Yiting;LI Guangyao;ZHANG Li(Department of Postgraduates,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan 250117,China;Department of Hematology,Liaocheng Affiliated Hospital of Shandong First Medical University(Liaocheng People’s Hospital),Liaocheng 252000,China)
出处
《山东第一医科大学(山东省医学科学院)学报》
2025年第5期271-275,共5页
Journal of Shandong First Medical University & Shandong Academy of Medical Sciences
基金
国家自然科学基金(81573772)
山东省医药卫生科技发展计划(202203040757)。
