摘要
精神分裂症是一种复杂且难治易反复的慢性精神障碍,其症状表现多样,严重影响患者的思维、情感和行为,给患者其家庭带来巨大负担。根据精神分裂症发病特点,可将其归属于中医学“癫狂”范畴。在中医学理论中精神分裂症与“肾虚痰瘀”理论关系密切,即肾虚脑髓失养为精神分裂症的发病之本,痰瘀互结脑络为关键病机。“肾虚痰瘀”理论的现代生物学基础,包括神经递质异常、炎症反应和维生素D水平异常。神经递质如多巴胺和谷氨酸的水平异常与精神分裂症症状相关,炎症反应在疾病发生发展中起重要作用,维生素D水平异常与精神分裂症风险增加有关。这些生物学因素与中医理论相互印证,为精神分裂症的中医治疗提供了科学依据。精神分裂症的中医病机强调了“肾虚痰瘀”理论的重要性,现代生物学研究为这一理论提供了有力支持。
Schizophrenia is a complex,chronic,and difficult-to-treat mental disorder characterized by diverse symptoms that severely affect a patient′s thoughts,emotions,and behavior,imposing a significant burden on the patient and their family.Based on the characteristics of the onset of schizophrenia,it can be categorized under the “mania and epilepsy” framework in traditional Chinese medicine(TCM).In TCM theory,schizophrenia is closely related to the “kidney deficiency and phlegm stasis” theory.This theory posits that kidney deficiency leading to inadequate nourishment of the brain is the root cause of schizophrenia,while the key pathogenic mechanism involves the obstruction of the brain meridians by phlegm stasis.The modern biological basis for the “kidney deficiency and phlegm stasis” theory includes abnormalities in neurotransmitters,inflammatory responses,and vitamin D levels.Abnormal levels of neurotransmitters such as dopamine and glutamate are associated with schizophrenia symptoms,inflammation plays an important role in the disease′s development,and vitamin D deficiency is linked to an increased risk of schizophrenia.These biological factors align with TCM theory,providing scientific support for TCM treatment of schizophrenia.The pathogenesis of schizophrenia in TCM highlights the importance of the “kidney deficiency and phlegm stasis” theory,and modern biological research provides strong evidence for this theory.
作者
殷涛
孙雪莹
曲春成
何伟志
王玉婕
赵永厚
YIN Tao;SUN Xueying;QU Chuncheng;HE Weizhi;WANG Yujie;ZHAO Yonghou(Heilongjiang University of Chinese Medicine,Harbin 150040,China;Heilongjiang Sengong General Hospital,Harbin 150040,China;Heilongjiang Mental Hospital,Harbin 150036,China)
出处
《世界中医药》
北大核心
2025年第5期867-871,共5页
World Chinese Medicine
基金
国家自然科学基金项目(82374438,81973747)
黑龙江省中医药科研项目(ZYW2023-111)。
关键词
精神分裂症
肾虚痰瘀
癫狂
病机
现代生物学
神经递质
炎症反应
维生素D
Schizophrenia
Kidney deficiency and phlegm stasis
Mania and epilepsy
Pathogenesis
Modern biology
Neurotransmitters
Inflammatory response
Vitamin D
