摘要
植物外泌体样纳米囊泡(PELNs)是一种新兴的纳米治疗剂及传递平台,不但具有疾病治疗潜力,而且可以作为药物的载体靶向疾病位点,起到治疗递送双重作用,且具有天然来源和低免疫原性等特点。本综述系统介绍了PELNs的抗炎、抗衰老、抗肿瘤、抗氧化应激、保肝、抗病毒等生物学功能,PELNs作为递送载体的内源性和外源性载药策略,递送药物和递送核酸等生物学应用,展现了PELNs作为治疗药物和递送载体的巨大潜力和优势。
Plant exosome-like nanovesicles(PELNs)are an emerging nanotherapeutic agent and delivery platform with the potential for disease treatment.They can be utilized as carriers for drugs to target disease sites,playing a dual role in therapeutic delivery.Additionally,PELNs exhibit natural characteristics and low immunogenicity.This review systematically introduces the biological functions of PELNs,including their anti-inflammatory,anti-aging,anti-tumor,antioxidant stress,hepatoprotective,and anti-viral properties.The biological applications,such as endogenous and exogenous drug-carrying strategies using PELNs as delivery vectors,highlight the significant potential and advantages of utilizing PELNs for therapeutic purposes and drug delivery.
作者
杨海飞
孙武
YANG Haifei;SUN Wu
出处
《中国医药生物技术》
2025年第3期313-317,共5页
Chinese Medicinal Biotechnology
基金
国家自然科学基金青年基金(82003198)。
