摘要
卵巢癌发病隐匿,早期诊断困难,确诊时往往已处于晚期,是女性生殖系统中致死率最高的疾病。卵巢癌的主要治疗方法是瘤体减灭术配合化疗,化疗药物具有毒性大、易复发、易耐药等特点,因而研究新药以辅助或替代化疗成为当今热点。多项研究表明,中药提取物具有抑制卵巢癌细胞增殖、侵袭、转移的作用。中药提取物联合化疗能够提高化疗有效性、减轻化疗的副作用、降低耐药性。本综述将中药提取物分为中药单体、单味中药提取物和复方中药提取物,并按作用机制将其归类,以期为卵巢癌的中西医结合治疗提供参考。
Ovarian cancer is considered the most deadly disease within the female reproductive system due to its subtle onset and challenges in early detection,often leading to diagnosis at an advanced stage.The primary treatment for ovarian cancer involves cytoreductive surgery combined with chemotherapy,with the most common combination being platinum drugs and paclitaxel.However,chemotherapeutic drugs are known for their high toxicity,potential for relapse,and susceptibility to resistance,prompting a current focus on researching new drugs to complement or potentially replace chemotherapy.Numerous studies have shown the ability of herbal extracts to inhibit the proliferation,invasion and metastasis of ovarian cancer cells.When combined with chemotherapy,herbal extracts have shown to enhance the effectiveness of treatment,minimize chemotherapy-related side effects,and reduce the risk of drug resistance.This review categorizes herbal extracts into herbal monomers,single-flavour herbal extracts,and compound herbal extracts based on their mechanisms of action,aiming to serve as a resource for integrating traditional Chinese medicine with Western medicine in the management of ovarian cancer.
作者
顾闵逸
程星
蒋敬庭
符圆圆
GU Minyi;CHENG Xing;JIANG Jingting;FU Yuanyuan
出处
《中国医药生物技术》
2025年第3期297-305,共9页
Chinese Medicinal Biotechnology
基金
国家自然科学基金(32270955、81972869)
江苏省中医药科技发展计划(MS2023084)
常州市科技局基金(CJ20210158)。
关键词
卵巢癌
中药提取物
中药单体
抗肿瘤机制
ovarian cancer
Chinese medicine extract
Chinese medicine monomer
anti-cancer mechanism
