摘要
对乙酰氨基苯酚(APAP)是一种用于治疗头疼和发烧症状的药物,其代谢产物会消耗肝脏内的谷胱甘肽(GSH),引起氧化应激.短时间内服用大量APAP会导致肝功能衰竭.本文以邻苯二酚(CAT)和2,5-二羟基对苯二甲酸(DHTA)为前驱体,采用一步水热法合成了具有强抗氧化能力和良好生物相容性的黄光碳点(D-CDs).在斑马鱼APAP肝损伤模型中,体内成像显示D-CDs可有效富集在斑马鱼肝脏部位.D-CDs增加了斑马鱼体内的超氧化物歧化酶(SOD)和GSH含量,减少了丙二醛(MDA)含量,有效改善了由APAP引起的氧化应激损伤.
Acetaminophen(APAP)is a drug used to treat headaches and fever symptoms,and its metabolites deplete glutathione(GSH)in the liver and cause oxidative stress.Taking large amounts of APAP in a short period of time can lead to liver failure.Yellow-emissive carbon dots(D-CDs)with strong antioxidant ability and good biocom⁃patibility were synthesized by one-step hydrothermal method using catechol(CAT)and 2,5-dihydroxyterephthalic acid(DHTA)as precursors.In the APAP-induced zebrafish liver injury model,in vivo imaging showed that D-CDs could be effectively enriched in the zebrafish liver.The superoxide dismutase(SOD)activity and GSH content was increased and the content of malondialdehyde(MDA)was reduced,which finally effectively improved APAPinduced oxidative stress injury in zebrafish.
作者
李燕
蔡皓
毕红
LI Yan;CAI Hao;BI Hong(College of Materials Science and Engineering,Anhui University,Hefei 230601,China)
出处
《高等学校化学学报》
北大核心
2025年第6期115-122,共8页
Chemical Journal of Chinese Universities
基金
国家自然科学基金(批准号:52172033)
国家重点研发计划项目(批准号:2021YFA1600202)资助.
