摘要
Background and Objectives:To systematically investigate the association between the dietary inflammatory index(DII)and gestational diabetes mellitus(GDM),with a focus on the role of BMI in this relationship.Methods and Study Design:A comprehensive search was conducted in PubMed,Embase,Web of Science,The Cochrane Library,Medline,CINAHL Complete,Chinese Periodical Full-text Database,China National Knowledge Infrastructure,Chinese Biomedical Literature Database,and China Wanfang Database for relevant observational studies published up to August 2023.The quality of the included studies was assessed using the Newcastle-Ottawa Scale.The pooled effect size was calculated using a random-effects model.Subgroup and meta-regression analyses were performed to explore potential sources of heterogeneity.Results:The study included 54,058 participants from 10 studies.Pregnant women with a higher DII,indicating a pro-inflammatory diet,had a significantly increased risk of GDM compared to those with a lower DII,indicating an anti-inflammatory diet(pooled OR:1.17,95%CI:1.01-1.36;I²=70%,p<0.001).Subgroup analyses revealed a stronger association in normal weight stratification(OR:1.25,95%CI:1.04-1.51),case-control studies(OR:1.45,95%CI:1.03-2.05),Asia(OR:1.26,95%CI:1.10-1.43),Europe(OR:1.27,95%CI:1.09-1.48),3-day dietary record as a dietary assessment tool(OR:1.30,95%CI:1.16-1.46),physical activity adjustment(OR:1.28,95%CI:1.13-1.46),and energy intake adjustment(OR:1.33,95%CI:1.19-1.48).Meta-regression analysis confirmed that geographical region significantly influenced heterogeneity between studies(p<0.05).Conclusions:An elevated DII is independently linked to a higher risk of GDM,especially in women of normal weight.
基金
supported by Nursing Research Fund of Fujian Maternity and Child Health Hospital(Grant number:YCXH22-20)
Startup Fund for scientific research of Fujian Medical University(Grant number:2022QH1190).
