摘要
目的:研究类风湿关节炎(rheumatoid arthritis,RA)和干燥综合征(Sj?gren’s syndrome,SS)患者类固醇激素变化及其与病情活动度之间的关系。方法:选取符合RA和SS诊断标准、年龄45~68岁的女性绝经患者。干预组共48例,其中RA患者23例、SS患者25,对照组纳入性别、年龄匹配的50例健康人群。采用液相色谱/串联质谱法测定干预组和对照组36种血清类固醇激素浓度,比较RA和SS患者血清类固醇激素水平与健康对照组的差异,探索RA和SS患者的红细胞沉降率(erythrocyte sedimentation rate,ESR)与血清类固醇激素水平的相关性。结果:相较于对照组,RA和SS患者各有14种类固醇激素水平发生显著变化,其中仅游离型+结合型2-羟基雌酮水平显著高于对照组,其他包括孕激素、雄激素、雌激素在内的13种类固醇激素水平均较对照组显著降低(FDR<0.05);RA和SS患者的部分血清雄激素和雌激素水平与ESR数值显著相关(P<0.05)。结论:RA和SS患者的血清类固醇激素水平异常,且存在代谢紊乱的情况,部分血清类固醇激素水平有可能成为提示疾病活动度的指标。
OBJECTIVE To investigate the changes in steroid hormones in patients with rheumatoid arthritis(RA) and Sj?gren's syndrome(SS) and their correlations with disease activity.METHODS Postmenopausal women at 45-68 years of age with a diagnosis of RA or SS were included in the intervention group(n=48),involving 23 RA patients and 25 SS patients.During the same period,50 gender-and age-matched healthy volunteers were included in the control group.Liquid chromatography/tandem mass spectrometry was used to determine the concentrations of 36 serum steroid hormones in the intervention group and control group.Differences in serum steroid hormone levels among RA patients,SS patients and healthy controls were compared.The correlation between erythrocyte sedimentation rate(ESR) and serum steroid hormone levels in RA and SS patients was identified.RESULTS Both RA and SS patients showed significant changes in 14 types of steroid hormones.Among them,only the levels of free + bound 2-hydroxyestrone were significantly higher than those in the control group,while the levels of 13 types of steroid hormones,including progesterone,androgen,and estrogen were significantly lower than those in the control group(FDR<0.05).Partial serum androgen and estrogen levels in RA and SS patients were significantly correlated with ESR values(P<0.05).CONCLUSION Patients with RA and SS have abnormal levels of steroid hormones and metabolic disorders.In addition,some serum steroid hormone levels may become indicators of disease activity.
作者
张莹莹
杨娜
严思敏
葛卫红
束庆
ZHANG Yingying;YANG Na;YAN Simin;GE Weihong;SHU Qing(Department of Pharmacy,Nanjing Hospital of Chinese Medicine,Jiangsu Nanjing 210001,China;Department of Pharmacy,Nanjing Drum Tower Hospital,The Affliated Hospital of Nanjing University Medical School,Jiangsu Nanjing 210008,China;Nanjing Medical Center for Clinical Pharmacy,Jiangsu Nanjing 210008,China)
出处
《中国医院药学杂志》
北大核心
2025年第9期1053-1058,共6页
Chinese Journal of Hospital Pharmacy
基金
江苏省老年医学会2023年度临床药学专项基金科研项目(编号:JGS2023MSYX011)
江苏省医院协会2024医院药事管理研究专项课题(编号:JSYGY-3-2024-YS38)
南京市卫生科技发展专项资金-医学重点科技发展项目(编号:ZKX21016)。
关键词
类固醇激素
类风湿关节炎
干燥综合征
液相色谱/串联质谱法
steroid hormone
rheumatoid arthritis
Sjogren's syndrome
liquid chromatography/tandem mass spectrometry
