摘要
肌肉减少症的发生与慢性肾脏病密切相关。近年来,慢性肾脏病患者肌肉减少症的发病率明显增高,影响着疾病的预后转归。近年来研究发现,慢性肾脏病合并肌肉减少症的发生与慢性炎症、氧化应激、线粒体功能障碍、激素水平异常、胰岛素抵抗、血管紧张素Ⅱ(AngⅡ)过多、维生素D缺乏、血液透析、运动障碍等因素有关。本文对其发病机制予以综述。
The occurrence of sarcopenia is closely related to chronic kidney disease.In recent years,the incidence rate of sarcopenia in chronic kidney disease patients has increased significantly,affecting the prognosis of the disease.In recent years,studies have found that the occurrence of sarcopenia in chronic kidney disease is related to factors such as chronic inflammation,oxidative stress,mitochondrial dysfunction,abnormal hormone levels,insulin resistance,excessive angiotensin Ⅱ,vitamin D deficiency,hemodialysis,and movement disorders.This article provides a review of its pathogenesis.
作者
李博浩
窦一田
张莉
张诗元
LI Bohao;DOU Yitian;ZHANG Li;ZHANG Shiyuan(Graduate School of Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)
出处
《中国临床研究》
2024年第12期1932-1935,共4页
Chinese Journal of Clinical Research
基金
天津市教委科研计划项目(自然科学)(2021ZD014)
天津市卫生健康委员会中西医结合科研课题(2023201)。
