摘要
目的:探讨多西环素(DOX)治疗儿童肺炎支原体肺炎(MPP)的有效性及安全性,分析低龄儿童应用DOX的安全性。方法:回顾性分析2023年1月至2024年3月北部战区总医院收治的MPP患儿临床资料。根据不同治疗方法分为DOX组与对照组,比较两组患儿住院时间、化验检查指标恢复情况及治疗后转归情况。结果:在有效性方面,DOX组患儿住院时间短于照组,白细胞水平更好,C反应蛋白好转时间短于对照组。在安全性方面,与对照组比较,DOX组肝功能异常发生率较高,胃肠道反应发生率较低。结论:DOX治疗MPP效果较好,肝功能异常发生率较高,但胃肠道不良反应发生率低于单用大环内酯类药物,可为DOX在低龄段儿童群体应用提供参考。
Objective:To explore the efficacy and safety of doxycycline(DOX)in the treatment of Mycoplasma pneumoniae pneumonia(MPP)in children,and to analyze the medication safety in young children.Methods:Retrospective analysis was performed on clinical data of children with MPP admitted into the General Hospital of Northern Theater Command from Jan.2023 to Mar.2024.All children were divided into the DOX group and control group according to different treatment methods.The length of stay,recovery of laboratory examination indicators and prognosis after treatment of two groups were compared.Results:Regarding efficacy,the length of stay in the DOX group was shorter than that in the control group,the white blood cell value level was better,and the improvement time of C-reactive protein was shorter than that in the control group.Regarding safety,compared with the control group,the proportion of abnormal liver function was higher and the proportion of gastrointestinal reactions was lower in the DOX group.Conclusion:DOX has a better therapeutic effect on MPP,with a higher frequency of abnormal liver function,yet the incidence of gastrointestinal adverse drug reactions is lower than that of macrolides alone,providing reference for the application in younger age groups.
作者
刘鑫
曾茜
李新灵
张潇
邢波
赵庆春
Liu Xin;Zeng Xi;Li Xinling;Zhang Xiao;Xing Bo;Zhao Qingchun(Shenyang Pharmaceutical University,Shenyang 110016,China;General Hospital of Northern Theater Command,Shenyang 110016,China)
出处
《儿科药学杂志》
2025年第6期41-43,共3页
Journal of Pediatric Pharmacy
基金
中国博士后科学基金面上项目,编号2023M734298
辽宁省自然科学基金联合基金(面上资助计划项目),编号2023-MSLH-354。
