摘要
阿尔茨海默病(AD)是一种严重的神经系统退行性疾病。约80%~90%AD患者伴随痴呆精神行为症状(BPSD),表现为一系列行为、心理和精神异常,会加速患者的认知恶化和早期死亡,因而被视为重要的临床症状。但AD伴随BPSD的发病机制至今不明,治疗手段有限。文中主要从神经影像学结合病理生理学等方面综合分析探索AD伴随BPSD的发生发展机制,并探讨可能的治疗应对措施等,以期为BPSD早期诊断和治疗提供借鉴。
Alzheimer's disease is a serious neurodegenerative disorder.Approximately 80%to 90%of patients are accompanied by behavioral and psychological symptoms of dementia(BPSD),which manifest as a series of behavioral,psychological and mental abnormalities.These abnormalities can accelerate the cognitive deterioration and premature death of patients,and thus are regarded as important clinical symptoms.However,the pathogenesis of BPSD is still unknown,and treatment methods are limited.The pathogenesis of BPSD from the perspective of neuroimaging and pathophysiology,and possible treatment measures were analyzed in this article,in order to provide references for the early diagnosis and treatment of BPSD.
作者
庞雪蕊
方苗
吴兴启
肖桂贤
戴雨龙
周珊珊
胡盼盼
汪凯
Pang Xuerui;Fang Miao;Wu Xingqi;Xiao Guixian;Dai Yulong;Zhou Shanshan;Hu Panpan;Wang Kai(Department of Neurology,the First Affiliated Hospital of Anhui Medical University,Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders,Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health,Hefei 230022,China;Department of Sleep Psychology,the Second Hospital of Anhui Medical University,Hefei 230601,China;School of Mental Health and Psychological Sciences,Anhui Medical University,Hefei230032,China)
出处
《中华神经科杂志》
北大核心
2025年第5期546-552,共7页
Chinese Journal of Neurology
基金
国家自然科学基金(82101498)
安徽省临床医学研究与转化项目(202304295107020039)。
关键词
阿尔茨海默病
焦虑
抑郁
睡眠障碍
妄想
幻觉
行为和行为机制
Alzheimer disease
Anxiety
Depression
Sleep disorders
Delusions
Hallucinations
Behavior and behavior mechanisms
