摘要
目的分析免疫组织化学检测在乳腺癌病理诊断中的应用价值。方法选取860例乳腺病变患者作为研究对象,根据乳腺病变病理结果分为研究组(恶性)和对照组(良性),每组430例。两组患者均采用免疫组织化学检测。比较两组患者的人类表皮生长因子受体2(C-erbB-2)、人表皮生长因子受体(EGFR)、细胞角蛋白5/6(CK5/6)、P16、P63、Ki67阳性表达率;比较研究组不同分级患者C-erbB-2阳性表达率及腋窝淋巴结转移情况。结果研究组患者C-erbB-2、EGFR、CK5/6、P16、P63、Ki67阳性表达率分别为40.7%、47.7%、38.1%、29.1%、64.7%、37.4%,显著高于对照组的17.4%、22.3%、20.5%、14.4%、23.7%、12.6%,差异具有统计学意义(P<0.05)。研究组A级患者C-erbB-2阳性表达率56.3%显著高于B级患者的25.1%,差异具有统计学意义(P<0.05)。研究组A级患者腋窝淋巴结转移率67.9%显著高于B级患者的19.1%,差异具有统计学意义(P<0.05)。结论免疫组织化学检测在乳腺癌病理诊断中具有较高的临床应用价值,雌激素受体、孕激素受体、C-erbB-2、EGFR、CK5/6、P16、P63、Ki67阳性表达率可作为诊断乳腺癌的重要依据,对于缩短乳腺癌患者的治疗周期、提高患者的生存质量及预后有重要意义,值得临床推广应用。
Objective To analyze the application value of immunohistochemical test in the pathological diagnosis of breast cancer.Methods A total of 860 patients with breast lesions were selected as research subjects and divided into study group(malignant)and control group(benign)according to the pathological results of breast lesions,with 430 cases in each group.Immunohistochemical tests were performed in both groups.Comparison of positive expression rates of human epidermal growth factor receptor 2(C-erbB-2),human epidermal growth factor receptor(EGFR),cytokeratin 5/6(CK5/6),P16,P63,Ki67 between the two groups,as well as positive expression rate of C-erbB-2 and axillary lymph-node metastasis in patients of different grades in the study group.Results The positive expression rates of C-erbB-2,EGFR,CK5/6,P16,P63 and Ki67 were 40.7%,47.7%,38.1%,29.1%,64.7%and 37.4%in the study group,which were significantly higher than 17.4%,22.3%,20.5%,14.4%,23.7%and 12.6%in the control group,and the difference was statistically significant(P<0.05).In the study group,the positive expression rate of C-erbB-2 in grade A patients was 56.3%,which was higher than 25.1%in grade B patients,and the difference was statistically significant(P<0.05).In the study group,the axillary lymph-node metastasis rate in grade A patients was 67.9%,which was higher than 19.1%in grade B patients,and the difference was statistically significant(P<0.05).Conclusion Immunohistochemical test has high clinical application value in the pathological diagnosis of breast cancer.The positive expression rate of estrogen receptor,progesterone receptor,C-erbB-2,EGFR,CK5/6,P16,P63,Ki67 can be used as important basis for diagnosis of breast cancer.It is of great significance to shorten the treatment cycle of breast cancer patients,improve the quality of life and prognosis of patients,and is worthy of clinical application.
作者
程倩
CHENG Qian(Pathology Department,Tieling Central Hospital,Tieling 112000,China)
出处
《中国现代药物应用》
2025年第9期59-61,共3页
Chinese Journal of Modern Drug Application
关键词
免疫组织化学检测
病理学诊断
乳腺癌
临床应用
Immunohistochemical test
Pathological diagnosis
Breast cancer
Clinical application
