摘要
急性缺血性卒中后,脑缺血再灌注损伤(cerebral ischemia-reperfusion injury,CIRI)可进一步损伤患者的神经功能,影响其预后。自噬在CIRI的病理过程中是一把“双刃剑”,其不同的激活程度以及在CIRI的不同时期,可对脑组织产生保护或损伤的相反作用。环鸟苷酸-腺苷酸合酶(cyclic guanosine monophosphate-adenosine monophosphate synthase,cGAS)-干扰素基因刺激因子(stimulator of interferon gene,STING)通路是先天免疫中重要的效应通路,突触融合蛋白17(syntaxin 17,STX17)是可溶性N-乙基顺丁烯二酰亚胺敏感性因子附着蛋白受体亚家族成员,两者在CIRI过程中对细胞自噬和线粒体自噬均具有重要的调节作用。本文对cGAS-STING通路和STX17在CIRI中调控自噬的机制及其相互关系进行综述,以期为CIRI的干预提供新的思路和依据。
After acute ischemic stroke,cerebral ischemia-reperfusion injury(CIRI)can further damage the neurological function of patients and affect their prognosis.Autophagy is a“double-edged sword”in the pathological process of CIRI.The varying stages and degrees of activation of CIRI can have opposing effects,either protecting or damaging brain tissue.The cyclic guanosine monophosphate-adenosine monophosphate synthase(cGAS)-stimulator of interferon gene(STING)pathway is an important pattern recognition and effector pathway in the innate immune response.Syntaxin 17(STX17)is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor subfamily.Both play significant regulatory roles in autophagy and mitophagy during the CIRI process.This article reviews the mechanisms and interrelationships between the cGAS-STING pathway and STX17 in regulating autophagy during CIRI,aiming to provide new ideas and evidence for the intervention of CIRI.
作者
杨航
高安邦
倪莹
马跃
高名同
YANG Hang;GAO Anbang;NI Ying;MA Yue;GAO Mingtong(School of Clinical Medicine,Shandong Second Medical University,Weifang 261035,China;Department of Emergency,Affiliated Hospital of Shandong Second Medical University,Weifang 261035,China)
出处
《中国卒中杂志》
北大核心
2025年第4期479-485,共7页
Chinese Journal of Stroke
基金
潍坊市卫生健康委员会科研项目(WFWJWK-2024-180)。
关键词
环鸟苷酸-腺苷酸合酶-干扰素基因刺激因子通路
突触融合蛋白17
自噬
脑缺血再灌注损伤
Cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon gene pathway
Syntaxin 17
Autophagy
Cerebral ischemia-reperfusion injury
