摘要
坏疽性脓皮病是一种自身炎症性疾病,属于中性粒细胞性皮肤病。常表现为快速发展的疼痛性皮肤溃疡,其溃疡特征为边界破坏和周围红斑。坏疽性脓皮病的病因尚不清楚,通常与多种其他免疫介导的疾病和多种潜在疾病相关,最常见的是炎症性肠病、血液疾病和恶性肿瘤、自身炎症综合征和炎症性关节炎等。本文综述坏疽性脓皮病相关系统合并症的研究进展。
Pyoderma gangrenosum(PG)is an autoinflammatory disorder that belongs to neutrophilic dermatosis.It often presents as a rapidly developing painful cutaneous ulcer,which is characterized by disruption of the border and peripheral erythema.The exact etiology of PG remains unknown,but it is often associated with various immune-mediated disorders.PG is associated with a wide range of underlying disorders,with inflammatory bowel disease,hematological diseases and malignancies,autoinflammatory syndromes and inflammatory arthritis as the most common underlying disorders.This review summarizes PG-related systemic complications.
作者
许秋云
纪超
Xu Qiuyun;Ji Chao(Department of Dermatology,the First Afiliated Hospital of Fujian Medical University,Fuzhou 350005,China)
出处
《中华皮肤科杂志》
北大核心
2025年第4期369-373,共5页
Chinese Journal of Dermatology
基金
福建省自然科学基金(2023J01618)
福建省免疫性皮肤病临床医学研究中心(2022Y2003)。
关键词
坏疽性脓皮病
系统合并症
炎症性肠病
治疗
发病机制
生物制剂
JAK抑制剂
Pyoderma gangrenosum
Systemic comorbidities
Inflammatory bowel disease
Therapy
Pathogenesis
Biologic agents
JAK inhibitor
