摘要
目的 探讨坏疽性脓皮病(PG)合并溃疡性结肠炎(UC)及结核患者的临床表现和治疗方法。方法 回顾性选取2024年1月22日于川北医学院附属医院皮肤科就诊的1例32岁女性PG合并UC及腰椎结核患者作为研究对象。分析该例患者的临床特点、诊断及治疗过程。分别以“坏疽性脓皮病”“溃疡性结肠炎”“结核”和"pyoderma gangrenosum""ulcerative colitis""tuberculosis"为中、英文关键词,在万方数据库和PubMed进行检索,检索PG合并UC、PG合并结核及PG同时合并UC和结核的相关文献。分析并总结文献报道的PG合并UC和结核的临床表现和治疗方法。结果 根据患者既往病史、临床表现、皮损活组织病理学等检查结果诊断为PG合并UC及腰椎结核。治疗10 d后,患者皮疹明显好转,表面结痂且无新发皮疹。文献复习结果显示,PG可以合并UC,PG也可以合并结核,但PG同时合并UC和结核国内外少见报道。PG合并结核需要谨慎用药,有可能导致结核活动。结论 当UC患者出现皮肤病变时,需尽早完善皮肤活检检查,避免漏诊。PG合并UC症状可能反复发生。PG合并结核需要谨慎用药,同时需长期随访结核的活动情况。
Objective To investigate the clinical manifestations and treatment of pyoderma gangrenosum(PG)complicated with ulcerative colitis(UC)and tuberculosis.Methods A 32-year-old female patient with PG,UC and lumbar tuberculosis who was treated in the Department of Dermatology,Affiliated Hospital of North Sichuan Medical College on January 22,2024 was retrospectively selected as the research object.The clinical features,diagnosis and treatment of this patient were analyzed."pyoderma gangrenosum""ulcerative colitis""tuberculosis"and"pyoderma gangrenosum""ulcerative colitis""tuberculosis"were used as Chinese and English keywords to search in Wanfang database and PubMed.The relevant literature was searched for PG complicated with UC,PG complicated with tuberculosis,and PG complicated with both UC and tuberculosis.The clinical manifestations and treatment methods of PG complicated with UC and tuberculosis reported in the literature were analyzed and summarized.Results According to the patient′s past medical history,clinical manifestations,skin lesion biopsy and other examination results,the patient was diagnosed as PG with UC and lumbar tuberculosis.After 10 days of treatment,the patient′s rash was significantly improved,with crust on the surface and no new rash.The results of literature review showed that PG could be complicated with UC,and PG could also be complicated with tuberculosis.However,there are few reports at home and abroad about the coexistence of PG with UC and tuberculosis.PG with tuberculosis requires careful medication and may lead to tuberculosis activity.Conclusion When UC patients have skin lesions,skin biopsy should be performed as soon as possible to avoid missed diagnosis.The symptoms of PG combined with UC may occur repeatedly.PG combined with tuberculosis requires careful medication and long-term follow-up of tuberculosis activity.
作者
明睿媛
何佳
李锋
熊心猜
王晓俊
MING Ruiyuan;HE Jia;LI Feng;XIONG Xincai;WANG Xiaojun(Department of Dermatology,Affiliated Hospital of North Sichuan Medical College,Nanchong,Sichuan 637000,China;Department of Dermatology,Suining First People′s Hospital,Suining,Sichuan 629000,China;Department of Anesthesiology,Chongqing People′s Hospital,Chongqing 401100,China)
出处
《检验医学与临床》
2025年第12期1713-1717,共5页
Laboratory Medicine and Clinic
基金
重庆市科卫联合医学科研面上项目(2022MSXM059)。
关键词
坏疽性脓皮病
溃疡性结肠炎
腰椎结核
皮肤疾病
炎症性肠病
pyoderma gangrenosum
ulcerative colitis
lumbar tuberculosis
skin diseases
inflammatory bowel disease
