摘要
铁死亡(ferroptosis)是一种铁依赖的细胞死亡方式,主要特征为铁过载、脂质过氧化物和活性氧蓄积.中医中“气血”是构成人体的重要组成部分,也是生命活动的动力和源泉.当“气血”失调时,会引发严重的疾病,所以调节“气血”是临床治疗疾病的基本原则和核心思想.研究表明,益气活血类中药可以通过调节铁稳态和抑制铁死亡在防治重大疾病方面发挥着积极作用.本文综述了益气活血类中药调控铁死亡防治各类重大疾病的研究进展,梳理现有的益气活血类中药防治铁死亡引发重大疾病的相关药物,为中药防治铁死亡引发的重大疾病提供新的思路.
Ferroptosis is an iron-dependent type of cell death,which mainly characterized by iron overload,lipid peroxidation and reactive oxygen species accumulation.In Chinese medicine“qi and blood”are an important part of the human body,as well as the power and source of life activities.Imbalance in“qi and blood”can lead to serious diseases,therefore,regulation of“qi and blood”serves as the fundamental principle and core concept in clinical disease treatment.Traditional Chinese medicine for qi-invigorating and bloodactivating play an active role in regulating iron homeostasis and inhibiting ferroptosis,thereby contributing to the prevention and treatment of major diseases.This review not only summarize recent research progress in regulating ferroptosis-induced major diseases using traditional Chinese medicine,but also categorize existing traditional Chinese medicine interventions that invigorate qi and activate blood circulation,providing new insights for preventing and treating ferroptosis-induced major diseases.
作者
刘耀东
王春秋
张月
闵军霞
王福俤
LIU YaoDong;WANG ChunQiu;ZHANG Yue;MIN JunXia;WANG FuDi(School of Pharmaceutical Science,Hengyang Medical School,University of South China,Hengyang 421001,China;Hengyang Medical School,University of South China,Hengyang 421001,China;School of Medicine,Zhejiang University,Hangzhou 310058,China)
出处
《中国科学:生命科学》
北大核心
2025年第4期722-741,共20页
Scientia Sinica(Vitae)
基金
湖南省大学生创新课题(S202210555238)资助项目。
关键词
铁死亡
铁稳态
中药
益气活血
ferroptosis
iron homeostasis
traditional Chinese medicine
qi-invigoration and blood-activation
