摘要
我们以往的工作表明,脑室注射催产素(OT)可增强电针镇痛效应,注射抗OT血清则明显削弱电针镇痛效应,电针时,脑内某些与痛和镇痛有关的核团内的OT含量也有明显变化。为进一步研究脑内OT增强电针镇痛与内源性阿片肽之间的关系,本工作用钾离子透入法引起大鼠甩尾反应的电流强度(mA)为痛反应指标,观察了侧脑室注射八肽胆囊收缩素(CCK-8)、纳洛酮(Nx)对OT增强电针镇痛的影响。
The cffect of oxytocin(OT)and cholecystokinin octapeptide(CCK-8)on EA anlgesia was studicd in rats.The incrcase of 20.7-39.86 and 9.0-45.0%in pain threshold was observed respectively when ICV of CCK-8 or naloxone were combined with EA,these increases were lower than that in saline-EA group significantly,while the simultaneous ICV of OT and CCK-8 or OT and na-loxone in combination with EA produced the increase of 76.2-116.6% and 41.8-104.5%in pain threshold separately.
作者
刘文彦
宋朝佑
杨俊
林葆城
Liu Wenyan;Song Chaoyou;Yang Jung;Lin Baocheng(Department of Neurobiology,Second Military Medical University Shanghai,200433)
出处
《针刺研究》
CSCD
1991年第3期231-232,共2页
Acupuncture Research
