摘要
目的通过双向孟德尔随机化(MR)方法探究多种类型糖尿病(DM)与青光眼发病率之间的相关性。方法使用双向MR分析方法,采用全基因组关联研究(GWAS)数据挑选出3类DM[1型糖尿病、2型糖尿病(T2DM)以及妊娠期糖尿病(GDM)]和青光眼高度相关的单核苷酸多态性(SNP)作为工具变量(IV),以分析不同类型DM与青光眼之间的双向因果关系。本研究采用MR-Egger、加权中位数法、逆方差加权、随机简单模型以及加权众数法进行综合分析,且对分析结果进行敏感性分析。结果双向MR分析结果显示,1型糖尿病与青光眼均无因果关系。正向MR分析结果显示,T2DM可能会促进青光眼的发生(IVW:OR=1.09,95%CI:1.05~1.14),而青光眼的发生不会提高T2DM的患病风险;同时多变量MR分析结果显示,T2DM可能是导致青光眼发生的风险因素。正向MR分析结果显示,GDM不会提高青光眼的发病率,但反向MR分析显示青光眼可能导致GDM的发生(IVW:OR=1.11,95%CI:1.02~1.21)。敏感性分析结果显示以上结果相对稳定且准确。结论T2DM可能会促进青光眼的发生,青光眼患者可能在妊娠期间更易发生GDM。
Objective To investigate the correlation between different diabetes mellitus(DM)subtypes and the incidence of glaucoma through bidirectional Mendelian randomization(MR)analysis.Methods Based on a bidirectional MR analysis framework,the highly correlated single nucleotide polymorphism(SNP)was selected from the genome-wide association study(GWAS)data as the instrumental variable(IV)for three DM subtypes[including type 1 diabetes mellitus(T1DM),type 2 diabetes mellitus(T2DM),and gestational diabetes mellitus(GDM)]and glaucoma to analyze the bidirectional causal relationship between different DM subtypes and glaucoma.Besides,the MR-Egger method,weighted median method,inverse-variance weighted method,simple random model,and weighted mode method were adopted to conduct a comprehensive analysis,and the obtained results were subjected to sensitivity analyses.Results The bidirectional MR analysis results revealed no causal association between T1DM and glaucoma.The forward MR analysis results indicated that T2DM may promote the development of glaucoma(IVW:OR=1.09,95%CI:1.05~1.14),while the development of glaucoma did not increase the risk of T2DM.Meanwhile,the multivariable MR analysis results showed that T2DM might be a potential risk factor for the development of glaucoma.The forward MR analysis results demonstrated that GDM did not increase the incidence of glaucoma;whereas the reverse MR analysis results suggested that glaucoma might increase the susceptibility to GDM(IVW:OR=1.11,95%CI:1.02~1.21).The sensitivity analysis results confirmed the stability and reliability of these findings.Conclusion T2DM may contribute to the development of glaucoma,and patients with glaucoma may exhibit heightened susceptibility to GDM during pregnancy.
作者
郁璐
董敏
杨奎亮
杨宁
邢怡桥
YU Lu;DONG Min;YANG Kuiliang;YANG Ning;XING Yiqiao(Department of Ophthalmology,Renmin Hospital of Wuhan University,Wuhan 430000,Hubei Province,China;Department of Ophthalmology,Aier Eye Hospital of Wuhan University,Wuhan 430000,Hubei Province,China)
出处
《眼科新进展》
北大核心
2025年第5期382-386,共5页
Recent Advances in Ophthalmology
基金
湖北省自然科学基金(编号:2020CFB240,2023AFC019)。
关键词
2型糖尿病
妊娠期糖尿病
1型糖尿病
青光眼
孟德尔随机化
type 2 diabetes mellitus
gestational diabetes mellitus
type 1 diabetes mellitus
glaucoma
Mendelian randomization
