摘要
胆道闭锁(biliary atresia,BA)是一种以胆道炎症和肝纤维化为特征的婴幼儿肝胆疾病,如不及时治疗,会迅速导致肝硬化和肝衰竭。间充质干细胞(mesenchymal stem cells,MSCs)是一种来自中胚层的多能干细胞,具有分化成多种细胞的潜力。MSCs主要依靠免疫调节、细胞转化能力及旁分泌机制调控肝纤维化。近年来,MSCs疗法成为抗肝纤维化的一种新型治疗手段,在临床中被逐渐运用。本综述通过对MSCs与BA肝纤维化的发病进行相关探讨,并归纳MSCs在治疗BA肝纤维化中的应用,以期为BA肝纤维化的治疗提供新的思路。
Biliary atresia(BA)is an infantile hepatobiliary disease characterized by biliary inflammation and hepatic fibrosis that can rapidly lead to cirrhosis and liver failure,when not treated in a timely manner.Mesenchymal stem cells(MSCs)are pluripotent stem cells derived from the mesoderm,showing the potential to differentiate into a wide range of cells.MSCs regulate liver fibrosis by immunomodulation,cellular transforming ability and paracrine mechanisms.In recent years,MSC therapy has become a novel therapeutic tool against liver fibrosis and has been gradually used in the clinic.This review provided an overview of the application of MSCs in treating liver fibrosis associated with BA and explored the relationship between MSCs and the development of BA liver fibrosis,aiming to providenovel ideas for the treatment of BA liver fibrosis.
作者
廖喜琳
金祝
Liao Xilin;Jin Zhu(Department of Pediatric Surgery,Guizhou Children's Hospital,Affiliated Hospital of Zunyi Medical University,Zunyi 563000,China)
出处
《中华小儿外科杂志》
北大核心
2025年第3期273-278,共6页
Chinese Journal of Pediatric Surgery
基金
黔科合基础-ZK[2023]一般555。
关键词
胆道闭锁
间充质干细胞
肝纤维化
Biliary atresia
Mesenchymal stem cells
Liver fibrosis
