摘要
胆道闭锁(biliary atresia,BA)是一种以炎症性及纤维性闭塞为特征的围产期发病的严重胆管疾病,目前胆道闭锁的发病机制尚不完全清楚,近年来,越来越多的证据表明胆道闭锁的发病与免疫失调导致的细胞损伤有关。本文将对胆道闭锁发病机制中免疫调控与胆管细胞损伤进行综述。
Biliary atresia(BA)is a severe cholestatic disease of the newborn,characterized by inflammatory and fibrotic obstruction of the bile ducts.Despite decades of research,the pathogenesis of BA remains incompletely understood.In recent years,accumulating evidence suggests that cellular injury induced by immune dysregulation may play a critical role in the development of BA.In this article,we provided a comprehensive review of the immunological mechanisms underlying the pathogenesis of BA,specifically focusing on immune regulation and bile duct cell injury.
作者
郝永兴
金祝
Hao Yongxing;Jin Zhu(Department of Pediatric Surgical,Guizhou Children's Hospital,Affiliated Hospital of Zunyi Medical University,Zunyi 563000,China)
出处
《中华小儿外科杂志》
北大核心
2025年第3期269-273,共5页
Chinese Journal of Pediatric Surgery
基金
黔科合基础-ZK[2023]一般555。
关键词
胆道闭锁
细胞损伤
免疫调控
Biliary atresia
Cell injury
Immune regulation
