摘要
Epithelial-mesenchymal transition(EMT)promotes several cancers by increasing tumor cell motility,disrupting epithelial cell phenotypes,apical-basal polarity,and intracellular connections,and enhancing tumor resistance to immunotherapy and chemotherapy.Mesenchymal-epithelial transition(MET),the opposite of EMT,causes tumor metastasis.EMT drives primary tumor cells,whereas MET inhibits them.Importantly,the complex network of EMT includes cell-cell interactions in the tumor microenvironment.Transcription factors,post-translational regulation,cytokine-mediated signaling,and microRNAs control EMT.In this review,we discussed how molecular mechanisms,signaling networks,and epithelial/mesenchymal states affect cancer treatment resistance and the tumor microenvironment.Research on immunotherapy and chemotherapy problems associated with EMT suggests that targeting EMT might be a potential cancer treatment resistance strategy.
基金
supported by the DST-INSPIRE(Department of Science&Technology-Innovation in Science Pursuit for Inspired Research)Fellowship(No.IF210078)
the Department of Science and Technology(Technology Development Program),Government of India(No.TDP/BDTD/54/2021/General)
the Indian Council of Medical Research-Department of Health Research(ICMR-DHR)Young Scientist Fellowship(F.No:R.12014/29/2022/HR).
