摘要
骨科疾病是全球范围内常见的健康问题,发病率逐年上升,给社会和医疗系统带来巨大负担,其诊疗也面临前所未有的挑战。笔者综合国内外前沿文献,结合自身临床工作经验与研究经历,归纳出未来10年骨科疾病诊疗领域面临的6大国际性挑战,包括骨坏死、骨感染、软骨损伤、难愈性创面、脊髓损伤和遗传发育性骨病。此类疾病普遍具有高发病率、病因复杂不明、危害严重和治疗手段有限等特点,在临床诊疗和基础研究方面迫切需要取得突破性进展。近年来,类器官、人工智能、脑机接口、基因编辑和干细胞疗法等新技术的相继涌现和转化应用,正深刻改变着传统骨科疾病诊疗模式与研究。为深入理解和把握骨科疾病诊疗研究面临的挑战与机遇,进而推动该领域的革新与发展,笔者从骨科疾病诊疗研究难点与痛点、潜在机遇与对策等方面进行阐述,为相关领域临床和科研工作者提供参考和启发,助力攻克6大国际性挑战。
Orthopedic diseases are a prevalent global health issue,with an increasing incidence year by year,imposing a significant burden on the society and the healthcare system.Research into their diagnosis and treatment faces unprecedented challenges.Based on a comprehensive review of cutting-edge literature from both domestic and international sources,as well as our own clinical and research experience,the authors identified six major international challenges in the diagnosis and treatment of orthopedic diseases over the next decade including osteonecrosis,bone infection,cartilage injury,refractory wound,spinal cord injury,and genetic developmental bone diseases.These diseases are generally characterized by high incidence rate,complex and unknown etiology,serious damage and limited treatment options.There is an urgent need for breakthroughs in both clinical diagnosis and treatment,as well as in basic research.In recent years,the emergence and transformation of new technologies such as organoid,artificial intelligence,brain computer interface,gene editing,and stem cell therapy are profoundly transforming the traditional approaches to the diagnosis,treatment and research of orthopedic diseases.To gain a deeper understanding and grasp of the challenges and opportunities in this field and to promote innovation and development,the authors elaborated on the difficulties,pain points as well as potential opportunities and countermeasures in the researches on the diagnosis and treatment of orthopedic diseases,aiming to provide references and inspirations for clinical and scientific researchers in related fields and contribute to solutions of the six major international challenges.
作者
张元维
陈晓
苏佳灿
Zhang Yuanwei;Chen Xiao;Su Jiacan(Department of Orthopedics,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China;Institute of Translational Medicine,Shanghai University,Shanghai 200444,China)
出处
《中华创伤杂志》
北大核心
2025年第3期231-236,共6页
Chinese Journal of Trauma
基金
国家自然科学基金重点项目(82230071)
上海市2024年度“科技创新行动计划”创新药械产品应用示范项目(24SF1902700)
上海申康研究型医师项目(创新团队)(SHDC2023CRT013)
上海市创新医疗器械应用示范项目(23SHS05700)。
关键词
骨坏死
脊髓损伤
类器官
人工智能
Osteonecrosis
Spinal cord injuries
Organoids
Artificial intelligence
