摘要
目的观察痔瘘洗剂在肛周脓肿术后创面愈合中的临床效果及其对肿瘤坏死因子-α(tumor necrosis factor-alpha,TNF-α)、干扰素-γ(interferon-gamma,IFN-γ)、白细胞介素-12(interleukin-12,IL-12)水平的影响。方法选取60例肛周脓肿术后患者,随机分为观察组和对照组,每组30例。观察组采用痔瘘洗剂熏洗,每日2次;对照组使用高锰酸钾溶液进行相同方式的熏洗。两组患者均治疗两周,比较两组患者的创面愈合时间、创面渗液评分、肉芽组织生长评分,以及两组患者治疗前后肉芽组织中TNF-α、IFN-γ、IL-12水平。结果与对照组比较,观察组患者的创面愈合时间显著缩短(P<0.05),创面渗液评分和肉芽组织生长评分均显著降低(P<0.05)。治疗后两组患者TNF-α、IFN-γ和IL-12水平均显著降低(P<0.05),且观察组降低程度更显著(P<0.05)。结论痔瘘洗剂能促进肛周脓肿术后创面愈合,减少术后炎症反应。
Objective To investigate the clinical effect of hemorrhoids-fistula lotion in wound healing after perianal abscess surgery and its regulatory effect on tumor necrosis factor-alpha(TNF-α),interferon-gamma(IFN-γ),and interleukin-12(IL-12).Methods A total of 60 patients after perianal abscess surgery were enrolled and randomly divided into observation group and control group,with 30 patients in each group.The patients in the observation group were given fumigation-washing therapy with hemorrhoids-fistula lotion twice a day,and those in the control group were given fumigation-washing therapy with potassium permanganate solution in the same way.Both groups were treated for 2 weeks,and the two groups were compared in terms of wound healing time,wound exudate score,and granulation tissue growth score,as well as the levels of TNF-α,IFN-γ,and IL-12 before and after treatment.Results Compared with the control group,the observation group had significantly shorter shedding time of wound slough and wound healing time(P<0.05)and significant reductions in wound exudate score and granulation tissue growth score(P<0.05).After treatment,both groups had significant reductions in the levels of TNF-α,IFN-γ,and IL-12(P<0.05),and the observation group had significantly greater reductions than the control group(P<0.05).Conclusion Hemorrhoids-fistula lotion can promote wound healing and reduce inflammatory response after perianal abscess surgery.
作者
唐冉
田慧
李明
王建民
TANG Ran;TIAN Hui;LI Ming;WANG Jianmin(Department of Coloproctology,The First Affiliated Hospital of Anhui University of Chinese Medicine,Anhui Hefei 230031,China;Anhui University of Chinese Medicine,Anhui Hefei 230012,China)
出处
《安徽中医药大学学报》
2025年第2期25-28,共4页
Journal of Anhui University of Chinese Medicine
基金
安徽省“十四五”省级中医优势特色专科项目(zyyfw20210087)
安徽省青年领军后备人才项目(2020qnqhxz20220011)。
关键词
痔瘘洗剂
肛周脓肿
创面愈合
炎症因子
Hemorrhoids-fistula lotion
Perianal abscess
Wound healing
Inflammatory factor
