摘要
目的针对多维复合营养粉(商品名:永瑞清)联合聚乙二醇电解质溶液应用于结肠镜检查中的效果进行分析。方法选取行结肠镜检查的150例患者,根据随机数字法分为对照组、观察Ⅰ组、观察Ⅱ组,每组50例。对照组给予常规半流质低渣饮食+3 L聚乙二醇电解质溶液,观察Ⅰ组给予永瑞清+3 L聚乙二醇电解质溶液,观察Ⅱ组给予永瑞清+2 L聚乙二醇电解质溶液。对比三组患者肠道准备效果、首次排便时间、最后一次排便情况、病变检出率、肠镜到达回盲部占比、进镜时间、退镜时间、患者再次服用意愿、不良反应发生情况、检查耐受度、满意度、肠镜检查前血糖情况,并比较观察Ⅰ组和观察Ⅱ组患者的受试产品口感。结果观察Ⅰ组、观察Ⅱ组肠道准备效果优良率分别为80%、78%,均高于对照组的58%,数据之间差异存在统计学意义(P<0.05);观察Ⅰ组、观察Ⅱ组肠道准备效果优良率对比,数据之间差异不存在统计学意义(P>0.05)。观察Ⅰ组首次排便时间(18.0±1.5)min、观察Ⅱ组患者首次排便时间(22.6±1.8)min均短于对照组的(32.4±2.4)min,且观察Ⅰ组短于观察Ⅱ组,数据之间差异存在统计学意义(P<0.05)。且观察Ⅰ组、观察Ⅱ组患者最后一次排便情况均优于对照组,数据之间差异存在统计学意义(P<0.05)。观察Ⅰ组、观察Ⅱ组病变检出率分别为32%、38%,均高于对照组的16%,数据之间差异存在统计学意义(P<0.05)。三组肠镜到达回盲部占比均为100%。对照组、观察Ⅰ组、观察Ⅱ组的进镜时间分别为(8.3±0.06)、(7.2±0.05)、(6.9±0.04)min,退镜时间分别为(13.6±0.11)、(10.2±0.09)、(9.5±0.08)min,三组进镜时间、退镜时间对比,对照组更长,数据之间差异存在统计学意义(P<0.05)。观察Ⅱ组、观察Ⅰ组患者愿意再次服用占比分别为80%、50%,均高于对照组的28%,且观察Ⅱ组最高,数据之间差异存在统计学意义(P<0.05)。观察Ⅱ组、观察Ⅰ组不良反应发生率分别为16%、20%,均低于对照组的42%,且观察Ⅱ组最低,数据之间差异存在统计学意义(P<0.05)。观察Ⅱ组、观察Ⅰ组不良反应发生率对比,数据之间差异不存在统计学意义(P>0.05)。对照组患者耐受度评分、满意度评分、空腹血糖正常占比分别为(2.3±0.03)分、(2.1±0.02)分、90%,观察Ⅰ组分别为(1.8±0.02)分、(1.5±0.02)分、100%,观察Ⅱ组分别为(0.4±0.01)分、(0.2±0.01)分、100%。观察Ⅰ组、观察Ⅱ组耐受度评分、满意度评分均低于对照组,且观察Ⅱ组低于观察Ⅰ组;观察Ⅰ组、观察Ⅱ组空腹血糖正常占比高于对照组,数据之间差异存在统计学意义(P<0.05)。观察Ⅱ组患者认为产品口感较好或极佳占比为80%,高于观察Ⅰ组的60%,数据之间差异存在统计学意义(P<0.05)。结论应用永瑞清联合2 L聚乙二醇电解质溶液对比常规饮食联合3 L聚乙二醇电解质溶液进行肠道准备,肠道清洁度更优,不良反应发生率低,患者再次服用意愿高,满意度较好,依从性和耐受性高,具有较高的应用推广价值。
Objective To analyze the effect of Multi-dimensional compound nutrient powder(trade name:Yongruiqing)combined with polyethylene glycol(PEG)electrolyte solution in bowel preparation before colonoscopy.Methods 150 patients who underwent colonoscopy were selected and divided into control group,observation groupⅠand observation groupⅡaccording to random numerical method,with 50 cases in each group.Control group was given conventional semi-fluid low residue diet+3 L polyethylene glycol electrolyte solution,observation groupⅠwas given Yongruiqing+3 L polyethylene glycol electrolyte solution,and observation groupⅡwas given Yongruiqing+2 L polyethylene glycol electrolyte solution.Comparison of effect of bowel preparation,first defecation time,last defecation time,lesion detection rate,percentage of enteroscopy reaching the ileocecal region,time of scope insertion,time of scope withdrawal,patients'willingness to take again,occurrence of adverse reactions,examination tolerance,satisfaction,and blood glucose before colonoscopy among the three groups,as well as the taste of the tested products between observation groupⅠand observation groupⅡ.Results The excellent rates of bowel preparation effect in observation groupⅠand observation groupⅡwere 80%and 78%,which were higher than 58%in control group,and the data difference was statistically significant(P<0.05);there was no statistical significance in excellent rates of bowel preparation effect between observation groupⅠand observation groupⅡ(P>0.05).The first defecation time of observation groupⅠwas(18.0±1.5)min,and the first defecation time of observation groupⅡwas(22.6±1.8)min,which was shorter than(32.4±2.4)min of control group;observation groupⅡwas shorter than observation groupⅡ;the data difference was statistically significant(P<0.05).The last defecation of observation groupⅠand observation groupⅡwas better than that of control group,and the data difference was statistically significant(P<0.05).The lesion detection rates of observation groupⅠand observation groupⅡwere 32%and 38%,which were higher than 16%of control group,and data the difference was statistically significant(P<0.05).The percentage of enteroscopy reaching the ileocecal region was 100%in all three groups.The time of scope insertion of control group,observation groupⅠand observation groupⅡwere(8.3±0.06),(7.2±0.05)and(6.9±0.04)min,and the time of scope withdrawal were(13.6±0.11),(10.2±0.09)and(9.5±0.08)min;the comparison of the time of scope insertion of the three groups showed that the control group was longer,and the data difference was statistically significant(P<0.05).The proportions of patients in observation groupⅡand observation groupⅠwho were willing to take it again were 80%and 50%,which were higher than 28%in control group,and observation groupⅡwas the highest,and the data difference was statistically significant(P<0.05).The incidence of adverse reactions in observation groupⅡand observation groupⅠwere 16%and 20%,which was lower than 42%in control group,and observation groupⅡwas the lowest,and the data difference was statistically significant(P<0.05).There was no statistical significance in the incidence of adverse reactions between observation groupⅡand observation groupⅠ(P>0.05).The tolerance score,satisfaction score and percentage of normal fasting blood glucose in control group were(2.3±0.03)points,(2.1±0.02)points and 90%;in observation groupⅠ,those were(1.8±0.02)points,(1.5±0.02)points and 100%;in observation groupⅡ,those were(0.4±0.01),(0.2±0.01)and 100%.The tolerance score and satisfaction score in observation groupⅠand observation groupⅡwere lower than those in control group,and observation groupⅡwas lower than observation groupⅠ;the percentage of normal fasting blood glucose in observation groupⅠand observation groupⅡwas higher than that in control group;the data difference was statistically significant(P<0.05).The percentage of patients in observation groupⅡwho thought the product tasted better or excellent was 80%,which was higher than 60%in observation groupⅠ,and the data difference was statistically significant(P<0.05).Conclusion Compared with conventional diet combined with 2 L polyethylene glycol electrolyte solution for bowel preparation,Yongruiqing combined with 3 L polyethylene glycol electrolyte solution has better bowel cleanliness,lower incidence of adverse reactions,higher willingness of patients to take it again,better satisfaction,higher compliance and tolerance,and has high application and promotion value.
出处
《中国现代药物应用》
2025年第6期6-11,共6页
Chinese Journal of Modern Drug Application
关键词
多维复合营养粉
聚乙二醇电解质溶液
肠道准备
结肠镜检查
Multi-dimensional compound nutrient powder
Polyethylene glycol electrolytes powder
Bowel preparation
Colonoscopy
