摘要
目的分析对重症肺炎合并2型糖尿病患者合用沙格列汀、二甲双胍、左氧氟沙星治疗的效果。方法选取2019年6月-2023年6月丹阳市人民医院接收的60例重症肺炎合并2型糖尿病患者,根据治疗方案不同分为对照组(30例)、观察组(30例)。对照组予以左氧氟沙星+二甲双胍治疗,观察组予以左氧氟沙星+二甲双胍+沙格列汀治疗,对比两组血糖水平、胰岛功能、炎性因子水平、不良反应发生情况。结果治疗后,观察组空腹血糖、餐后2 h血糖、糖化血红蛋白、C反应蛋白、肿瘤坏死因子-α、白细胞介素-6水平、胰岛素抵抗指数均低于对照组,胰岛β细胞功能指数高于对照组,差异均有统计学意义(P均<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论对于重症肺炎合并2型糖尿病患者而言,合用二甲双胍、左氧氟沙星及沙格列汀治疗有一定的优势,其不仅能够有效控制血糖水平,且安全性更高。
Objective To analyze the effect of saxagliptin,metformin and levofloxacin in patients with severe pneumo-nia complicated with type 2 diabetes mellitus.Methods From June 2019 to June 2023,60 patients with severe pneu-monia complicated with type 2 diabetes mellitus received by Danyang People's Hospital were selected and divided into control group(30 cases)and observation group(30 cases)according to different treatment schemes.The control group was treated with levofloxacin+metformin,and the observation group was treated with levofloxacin+metformin+saxagliptin.The blood glucose levels,islet function,inflammatory factor levels and adverse reactions were compared between the two groups.Results After treatment,the levels of fasting blood glucose,2-hour postprandial blood glu-cose,glycated hemoglobin A1c,C-reactive protein,tumor necrosis factor-α,interleukin-6 and insulin resistance in-dex in the observation group were lower than those in the control group,and the isletβ-cell function index was higher than that in the control group,the differences were statistically significant(all P<0.05).There was no significant differ-ence in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion For patients with severe pneumonia complicated with type 2 diabetes mellitus,the combination of metformin,levofloxacin and saxagliptin has certain advantages,which can not only effectively control blood glucose levels,but also has higher safety.
作者
吴云
蔡俊丹
马颖颖
WU Yun;CAI Jundan;MA Yingying(Department of Critical Care Medicine,Danyang People's Hospital,Danyang 212300,Jiangsu,China)
出处
《糖尿病新世界》
2025年第3期82-85,共4页
Diabetes New World
关键词
重症肺炎
2型糖尿病
沙格利汀
二甲双胍
左氧氟沙星
血糖水平
Severe pneumonia
Type 2 diabetes mellitus
Saxagliptin
Metformin
Levofloxacin
Blood glucose level
