摘要
目的 观察普罗布考对肾病综合征(nephrotic syndrome, NS)患者血清炎症因子、氧化应激、脂代谢、肾功能及足细胞功能的影响。方法 76例NS患者根据随机数字表法分为对照组和观察组,每组38例,对照组患者入院后予以醋酸泼尼松片联合环磷酰胺口服治疗;观察组在对照组治疗基础上口服普罗布考0.5 g/次,2次/天。两组均连续治疗12周。检测两组患者治疗前后血清炎症因子血清白细胞介素6(interleukin 6,IL-6)、肿瘤坏死因子α(tumor necrosis factor alpha, TNF-α)、超敏C反应蛋白(hypersensitive C-reactive protein, hs-CRP),氧化应激指标血清超氧化物歧化酶(superoxide dismutase, SOD)、丙二醛(malondialdehyde, MDA)、8-羟基脱氧鸟昔(8-hydroxy deoxyguanosine, 8-OHdG),脂代谢指标血清甘油三酯(triglyceride, TG)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol, HDL-C)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol, LDL-C)、总胆固醇(total cholesterol, TC),肾功能指标血肌酐(serum creatinine, Scr)、尿素氮(blood urea nitrogen, BUN)、24 h尿蛋白定量,足细胞功能指标足细胞标志蛋白(podocalyxin, PCX)及足细胞裂孔膜蛋白nephrin表达水平。结果 两组患者治疗前血清炎症因子、氧化应激、脂代谢、肾功能及足细胞功能指标比较差异均无统计学意义(P均>0.05);观察组治疗后SOD升高较对照组更明显(P<0.05),而MDA、8-OHdG、TG、HDL-C、LDL-C、TC、血清炎症因子、肾功能及足细胞功能指标降低较对照组更为明显(P均<0.05);两组患者治疗期间均未出现严重不良反应。结论 普罗布考辅助治疗可明显减轻NS患者炎症及氧化应激反应,改善脂代谢、肾功能及足细胞功能。
Objective To observe the effects of Probucol on serum inflammatory factors,oxidative stress,lipid me-tabolism,renal function and podocyte function in patients with nephrotic syndrome(NS).Methods A total of 76 pa-tients with NS were randomly divided into control group and observation group according to numerical table method,with38 patients in each,the patients in the control group were orally treated with Prednisone acetate tablet combined with Cy-clophosphamide after admission,and the patients in observation group were orally treated with Probucol 0.5 g/time,twice/d on the basis of the control group.Both groups were treated continuously for 12 weeks,Serum inflammatory fac-tor serum interleukin 6(Il-6),tumor nccrosis factor alpha(TNF-a),hypersensitive C-reactive protein(hsCRP),oxida-tive stress indexes superoxide dismutase(SOD),malondialdehyde(MDA),8-hydroxy deoxyguanosine(8-OHdG),lipidmetabolism triglyceride(TG),high density lipoprotein cholesterol(HDL.-C),low density lipoprotein cholesterol(LDL-C),total cholesterol(TC),renal function indexes serum creatinine(Scr),blood urea nitrogen(BUN),24 h urinary pro-tein quantification,podocyte function indexes podocalyxin(PCX)and podocin nephrin of patients in both groups beforeand after treatment were measured.ResultsThere were no significant differences in serum inflammatory factors,oxida-tive stress,lipid metabolism,renal function and podocytefunction between the two groups before treatment(all P>0.05).The level of SOD in the observation group washigher than that in the control group after treatment(P<0.05),but the levels of MDA,8-OHdG,TG,HDL-C,LDL-C,TC,serum inflammatory factors,renal function and podocyte function were significantly lower than those in thecontrol group(all P<0.05),no serious adverse reactions occurred during treatments in both groups.Conclusion Theadjuvant therapy of Probucol for the patients with NS can significantly reduce the inflammatory and oxidative stress reac-tion,improve lipid metabolism,renal function and podocyte function.
作者
逄玉涛
肖瑞峰
杨成
PANG Yutao;XIAO Ruifeng;YANG Cheng(Department of Nephrology,General Hospital of Central Theater Command,Wuhan Hubei 430070,China)
出处
《联勤军事医学》
2024年第12期1027-1031,共5页
Military Medicine of Joint Logistics
基金
中部战区总医院育英计划项目(ZZYFH202120)。
关键词
普罗布考
肾病综合征
炎症因子
氧化应激
足细胞功能
Probucol
Nephrotic syndrome
Inflammatory factor
Oxidative stress
Podocyte function
