摘要
Ginkgo biloba is a deciduous tree belonging to Ginkgo,Ginkgoaceae.It is often used to treat dizziness,tinnitus,vertigo,hyperlipidemia and diabetic peripheral neuropathy.Bilobalide is a natural active compound derived from the leaves and fruits of G.biloba,which exhibits a range of pharmacological effects,including anti-inflammatory properties,obesity treatment,neuroprotection,and hepatoprotection.This paper provides a comprehensive review of the pharmacological actions and molecular mechanisms of bilobalide,with a particular focus on its roles in anti-inflammatory responses,metabolic regulation,neuroprotection,and hepatoprotection.Research has demonstrated that bilobalide exerts its pharmacological effects through the regulation of various signaling pathways,including AMPK/SIRT1/mTOR,STAT3,and Nrf-2/HO-1.This paper aims to establish a theoretical foundation for the further investigation,development,and application of bilobalide.
基金
Supported by Heilongjiang Provincial Key Research and Development Plan Guidance Project(GZ20220039)
Central Government Supports Local College Reform and Development Fund Talent Training Projects(2020GSP16).
