摘要
失眠是一种因入睡困难或睡眠维持时间短暂导致睡眠质量低下而影响正常生活的疾病。其发病因素众多,病理机制复杂,病程常缠绵难愈,不仅患病率高,而且极易复发,给个人及家庭带来了沉重的心理负担和经济压力。目前,西医以对症治疗为主,疗效欠佳,相比之下,中医药治疗失眠的独特优势日益凸显。酸枣仁作为安神药之一,具有养心补肝、宁心安神、敛汗生津等功效,近年来其单体及复合制剂临床上常被用于失眠的治疗,并取得了显著疗效。其治疗失眠的机制可能与调节γ-氨基丁酸(GABA)等神经递质和内源性因子、调控下丘脑-垂体-肾上腺轴(hypothalamic-pituitary-adrenal axis,HPA轴)和微生物群-肠-脑轴、改善细胞能量代谢、干预环磷酸腺苷(c AMP)/蛋白激酶A(PKA)及丝裂素活化蛋白激酶信号通路等有关。该文对酸枣仁有效成分、经典配伍及复合制剂治疗失眠的作用机制及研究进展进行总结与归纳,以期为酸枣仁的临床应用及中医药治疗失眠提供参考价值。
Insomnia is a disease that affects normal life due to difficulty falling asleep or short sleep maintenance time resulting in poor sleep quality.Its pathogenic factors are numerous,the pathological mechanism is complex,the course of the disease is often lingering and difficult to cure,not only the prevalence is high,but also easy to relapse,which brings a heavy psychological burden and economic pressure to individuals and families.At present,Western medicine is based on symptomatic treatment,with poor effect.In contrast,the unique advantages of traditional Chinese medicine in the treatment of insomnia are increasingly prominent.As one of the tranquilizing drugs,Suanzaoren(Ziziphi Spinosae Semen,SZS)monomer has the effects of nourishing the heart and tonifying the liver,calming the heart and calming the mind,collecting sweat and producing fluid,etc.In recent years,its monomeric and composite formulation are often used in clinical insomnia treatment and have achieved remarkable effects.The mechanism of its treatment of insomnia may be related to the regulation of neurotransmitters and endogenous factors such asγ-aminobutyric acid(GABA),the regulation of the hypothalamic-pituitary-adrenal(HPA)axis and microbiota-gut-brain axis,the improvement of energy metabolism of cells,and intervention in the cyclic adenosine monophosphate(cAMP)/protein kinase A(PKA)and mitotin-activated protein kinase signaling pathway.This article is to summarize the mechanism of action and research progress of the effective ingredients,classic compatibility and compound formulation of SZS in the treatment of insomnia,in order to provide reference value for the clinical application of SZS and Chinese medicine in the treatment of insomnia.
作者
秦梦歌
张金培
QIN Mengge;ZHANG Jinpei(Shaanxi University of Chinese Medicine,Xianyang 712000,Shaanxi,China;Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000,Shaanxi,China)
出处
《辽宁中医药大学学报》
2025年第3期78-86,共9页
Journal of Liaoning University of Traditional Chinese Medicine
基金
国家自然科学基金(81973843,82374236)
咸阳市自然科学基金项目(2018k02-89)。
关键词
失眠
酸枣仁
经典配伍
复合制剂
作用机制
insomnia
Suanzaoren(Ziziphi Spinosae Semen)
classic compatibility
compound formulation
mechanism of action
