摘要
目的:分析子痫前期(PE)患者孕中期非高密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值(non-HDL-C/HDL-C)与不良妊娠结局关系及预测价值。方法:收集2022年6月-2023年12月本院产前检查并分娩的PE患者102例临床资料,根据是否出现不良妊娠结局分为不良妊娠组(n=38)与良好妊娠组(n=64),收集患者临床资料,计算non-HDL-C值、non-HDL-C/HDL-C值;采用多因素logistic回归分析探讨PE患者不良妊娠结局影响因素;采用受试者工作特性(ROC)曲线分析non-HDL-C/HDL-C对PE患者不良妊娠结局的预测价值。结果:不良妊娠组non-HDL-C(5.91±0.23 mmol/L)、non-HDL-C/HDL-C(3.79±0.25)均高于良好妊娠组(4.63±0.27 mmol/L、2.71±0.13)(均P<0.05)。多因素回归分析,24h尿蛋白升高、血小板计数降低、non-HDL-C升高、non-HDL-C/HDL-C升高是PE患者不良妊娠结局危险因素(P<0.05);non-HDL-C、non-HDL-C/HDL-C预测PE患者不良妊娠结局的曲线下面积分别为0.793、0.925。结论:24h尿蛋白升高、血小板计数降低、non-HDL-C升高、non-HDL-C/HDL-C升高是PE患者不良妊娠结局危险因素,且non-HDL-C/HDL-C预测PE患者不良妊娠结局价值较好。
Objective: To analyze the correlation between non-high density lipoprotein(HDL-C)/HDL-C ratio of the pregnant women with preeclampsia(PE) and their adverse pregnancy outcomes, and explore the value of non-HDL-C/HDL-C ratio of the women with PE for predicting their adverse pregnancy outcomes. Methods: The clinical data of 102 pregnant women with PE who were examined and delivered in the hospital from June 2022 to December 2023 were collected in this study. These women were divided into two groups according to whether the adverse pregnancy outcomes of the women occurred or not, including 38 women with the adverse pregnancy outcomes in group A and 64 women with the normal pregnancy outcomes in group B. The clinical data of the women in the two groups were collected, and the non-HDL-C value and the non-HDL-C/HDL-C ratio of the women in the two groups were calculated. The influencing factors of the adverse pregnancy outcomes of the women with PE were explored by multivariate logistic regression. Receiver operator characteristic(ROC) curve was used to analyze the predictive value of the non-HDL-C/HDL-C ratio of the women with PE for their adverse pregnancy outcomes. Results: The non-HDL-C level(5.91±0.23 mmol/L) and the non-HDL-C/HDL-C ratio(3.79±0.25) of the women in group A were significantly higher than those(4.63±0.27 mmol/L and 2.71±0.13) of the women in group B(all P<0.05). Multivariate regression analysis showed that the increased 24h urine protein, the decreased platelet count, the increased non-HDL-C level and the non-HDL-C/HDL-C ratio of the women with PE were the risk factors of their adverse pregnancy outcomes(P<0.05). The area under the curve of the non-HDL-C level and the non-HDL-C/HDL-C ratio of the women with PE for predicting their adverse pregnancy outcomes were 0.793and 0.925.Conclusion:The increased 24hurinary protein,non-HDL-C level and nonHDL-C/HDL-C ratio and the decreased platelet count of the pregnant women with PE are the risk factors of their adverse pregnancy outcomes,and the non-HDL-C/HDL-C ratio of the pregnant women with PE has higher predictive value for their occurrence of adverse pregnancy outcomes.
作者
任艳华
王月
徐闻铂
王新彦
刘欣悦
刘春稳
孙志敏
REN Yanhua;WANG Yue;XU Wenbo;WANG Xinyan;LIU Xinyue;LIU Chunwen;SUN Zhimin(Cangzhou Maternal and Child Health Care Hospital,Cangzhou,Hebei Province,061000)
出处
《中国计划生育学杂志》
2025年第2期414-418,共5页
Chinese Journal of Family Planning
基金
河北省医学科学研究课题(20241789)
沧州市重点研发计划指导项目(222106053)。
