摘要
目的:分析宫颈癌患者阴道微生物群变化及其与肿瘤标志物的相关性。方法:选择2021年5月-2024年5月本院诊治的宫颈癌患者103例为宫颈癌组、宫颈上皮内瘤变患者100例设为良性组、体检健康女性90例为对照组。检测并且分析3组阴道微生物群、血清肿瘤标志物[鳞状细胞癌抗原(SCC)、癌胚抗原(CEA)、癌抗原125(CA125)]。采用Spearman等级相关分析探讨宫颈癌患者阴道菌群与SCC、CEA、CA125水平相关性。结果:乳杆菌阴性、加德纳菌阳性、厌氧菌阳性、链球菌阳性及大肠杆菌阳性比例,以及血清SCC、CEA、CA125水平在对照组、良性组、宫颈癌组均依次升高,且宫颈癌组随着分化程度增加乳杆菌阴性、加德纳菌阳性、厌氧菌阳性、链球菌阳性及大肠杆菌阳性比例逐渐降低;Spearman相关分析显示,宫颈癌患者阴道微生物群失调与SCC、CEA、CA125水平均呈正相关(均P<0.05)。结论:宫颈癌患者阴道微生物群失调明显,且与肿瘤标志物SCC、CEA、CA125水平呈正相关。
Objective: To analyze the changes of the vaginal microbiota of women with cervical cancer, and to study its correlation with the tumor markers levels of the women. Methods: A total of 103 women with cervical cancer who treated in the hospital were selected in group A and and 100 women with cervical intraepithelial neoplasia were selected in group B from May 2021 to May 2024. 90 healthy women with physical examination were selected in group C during the same period. The vaginal microbiota and the levels of the serum tumor markers, such as squamous cell carcinoma antigen(SCC), carcinoembryonic antigen(CEA) and cancer antigen 125(CA125), of the women in the three groups were detected and analyzed. The correlation between the vaginal flora of the women in group A and their SCC, CEA and CA125 levels was investigated by Spearman correlation analysis. Results: The proportions of Lactobacillus negative, Gardnerella positive, anaerobes positive, Streptococcus positive and Escherichia coli positive, and the levels of THE serum SCC, CEA and CA125 of the women in group C, in group B and in group A had increased gradually. The proportions of Lactobacillus negative, Gardnerella positive, anaerobes positive, Streptococcus positive and Escherichia coli positive of the women in group A had decreased gradually with the differentiation degree increase of their cervical cancer. Spearman correlation analysis showed that the vaginal microbiota imbalance of the women in group A was positively correlated with their SCC, CEA and CA125 levels(all P<0.05). Conclusion: The vaginal microbiota imbalance of the women with cervical cancer is obvious, and which is positively correlated with the levels of the tumor markers, such as SCC, CEA and CA125, of the women.
作者
高经纬
冯倩倩
冷婷
杨静怡
王慧慧
GAO Jingwei;FENG Qianqian;LENG Ting;YANG Jingyi;WANG Huihui(Suzhou Municipal Hospital,Suzhou,Jiangsu Province,215000)
出处
《中国计划生育学杂志》
2025年第2期371-375,共5页
Chinese Journal of Family Planning
关键词
宫颈癌
阴道菌群
肿瘤标志物
相关性
Cervical cancer
Vaginal microbiota
Tumor markers
Correlation
