摘要
目的 探讨阿帕替尼联合伊立替康辅助治疗术后转移性胃癌的效果及对miR-92a、miR-130b相对表达量的影响。方法 选取2021年3月至2023年3月收治的100例术后转移性胃癌患者为研究对象,将其随机分为对照组和观察组,各50例。两组均采取常规治疗,对照组采用伊立替康辅助治疗,观察组在对照组基础上加阿帕替尼治疗。比较两组的治疗效果。结果 观察组的疾病控制率高于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的miR-92a、miR-130b相对表达量低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的癌抗原125(CA125)、癌胚抗原(CEA)、糖类抗原19-9(CA19-9)、肿瘤特异性生长因子(TSGF)水平低于对照组,差异具有统计学意义(P<0.05)。观察组的不良反应总发生率低于对照组,差异具有统计学意义(P<0.05)。结论 阿帕替尼联合伊立替康辅助治疗术后转移性胃癌患者的效果显著,不仅能够抑制miR-92a、miR-130b相对表达量,还能调节肿瘤标志物水平,值得推广。
Objective To investigate the effect of apatinib combined with irinotecan in adjuvant treatment of postoperative metastatic gastric cancer and its influences on the relative expression of miR-92a and miR-130b.Methods A total of 100 patients with postoperative metastatic gastric cancer admitted from March 2021 to March 2023 were selected as the research objects and randomly divided into control group and observation group,with 50 cases in each group.Both groups were treated with conventional therapy,the control group was adjuvant treated with irinotecan,and the observation group was treated with apatinib on the basis of the control group.The therapeutic effects of the two groups were compared.Results The disease control rate in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the relative expression of miR-92a and miR-130b in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of cancer antigen 125(CA125),carcinoembryonic antigen(CEA),carbohydrate antigen 19-9(CA19-9)and tumor specific growth factor(TSGF)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Apatinib combined with irinotecan has a significant effect in patients with postoperative metastatic gastric cancer,it can not only inhibit the relative expression of miR-92a and miR-130b,but also regulate the levels of tumor markers,which is worthy of promotion.
作者
张婧博
高瑞君
杨柳
ZHANG Jingbo;GAO Ruijun;YANG Liu(Medical Laboratory Technology Teaching and Research Section,Shaanxi Energy Vocational and Technical Institute,Xianyang 712000;Plastic Surgery Department,Xijing Hospital,Xi'an 710032,China)
出处
《临床医学研究与实践》
2025年第3期51-54,共4页
Clinical Research and Practice
基金
咸阳市科学技术局重点研发计划项目(No.L2022ZDYFSF062)
陕西能源职业技术学院2021年度校级青年专项(自然一般)项目(No.2021QN03)。
