摘要
2型糖尿病(type 2 diabetes mellitus,T2DM)与子宫内膜癌(endometrial cancer,EC)的发病率较高、侵袭性增加有关。T2DM患者的高血糖、高胰岛素状态、胰岛素抵抗、肥胖作为潜在的EC发病机制,已得到了广泛的研究,肠道菌群失调可能是T2DM相关EC的关键因素。综述T2DM与EC、T2DM与肠道菌群、T2DM相关EC与肠道菌群之间的联系在微小RNA(miRNA)异常表达、线粒体功能障碍、炎症与脂联素水平方面的表现、肠道菌群治疗T2DM相关EC的进展,以期以肠道菌群为切入点为防治T2DM相关EC提供相关理论依据。
Type 2 diabetes mellitus(T2DM)is related to the higher incidence and the increased invasiveness of endometrial cancer(EC).Hyperglycemia,hyperinsulinemia,insulin resistance and obesity in patients with T2DM have been widely studied as potential pathogenesis of EC,and the imbalance of intestinal flora may be the key factor of T2DM-related EC.This paper summarizes the relationships between T2DM and EC,T2DM and intestinal flora,T2DM-related EC and intestinal flora,including the abnormal expression of microRNA,mitochondrial dysfunction,inflammation and adiponectin level,and the progress of intestinal flora in treating T2DM-related EC,in order to provide a reference for the prevention and treatment of T2DM-related EC from the perspective of intestinal flora.
作者
王芳
万桃
杨永秀(审校)
WANG Fang;WAN Tao;YANG Yong-xiu(The First Clinical Medical College of Lanzhou University,Lanzhou 730000,China;Department of Obstetrics and Gynecology,The First Hospital of Lanzhou University,Gansu Provincial Clinical Research Center for Gynecological Oncology,Lanzhou 730000,China)
出处
《国际生殖健康/计划生育杂志》
2024年第3期249-253,共5页
Journal of International Reproductive Health/Family Planning
关键词
胃肠道微生物组
糖尿病
2型
子宫内膜肿瘤
治疗
Gastrointestinal microbiome
Diabetes mellitus,type 2
Endometrial neoplasms
Therapy
