摘要
目的:荟萃分析方法评价5-羟色胺(5-HT)1A受体部分激动剂治疗功能性消化不良(FD)的临床疗效及安全性。方法:计算机检索PubMed、Web of Science、CNKI等数据库建库起公开发表的5-HT1A受体部分激动剂治疗FD的随机对照研究(RCT)。RevMan 5.4软件对纳入的资料荟萃分析,并进行亚组分析、分层分析,评价5-HT1A受体部分激动剂对FD的疗效及安全性。结果:纳入19项RCT,共计1575例患者(治疗组801例,对照组774例)。荟萃分析显示:治疗组总有效率高于对照组(OR=4.18,95%CI:3.05~5.73,P<0.00001),而消化道症状评分(SMD=-1.30,95%CI:-1.95~-0.64,P=0.0001)、焦虑状态评分(SMD=-1.22,95%CI:-1.79~-0.65,P<0.0001)和抑郁状态评分(SMD=-1.52,95%CI:-2.41~-0.63,P=0.0008)均低于对照组,嗜睡(OR=4.78,95%CI:1.80~12.70,P<0.05)、口干(OR=3.07,95%CI:1.31~7.19,P<0.05)发生率均高于对照组。结论:与常规或安慰剂治疗相比,联合应用5-HT1A受体部分激动剂能提高总体疗效,但嗜睡及口干发生率较高。
Objective:To evaluate the clinical efficacy and safety of partial agonists of serotonin receptor 1A(5-HT1A)in the treatment of functional dyspepsia(FD)by meta-analysis.Methods:Published randomized controlled trials(RCT)of 5-HT1A receptor partial agonist in the treatment of FD was collected by searching PubMed,Web of Science,CNKI,and other databases.The data were analyzed using RevMan 5.4,and subgroup analysis and stratification analysis were conducted to assess the efficacy and safety of 5-HT1A receptor partial agonists on FD.Results:A total of 19 RCTs involving 1575 patients were included,with 801 patients in the treatment group and 774 patients in the control group.Meta-analysis showed the total effective rate of the treatment group was higher than that of the control group(OR=4.18,95%CI:3.05-5.73,P<0.00001),while the gastrointestinal symptom score(SMD=-1.30,95%CI:-1.95--0.64,P=0.0001),anxiety state score(SMD=-1.22,95%CI:-1.79--0.65,P<0.0001),and depression state score(SMD=-1.52,95%CI:-2.41--0.63,P=0.0008)were lower than those of the control group.The incidences of sleepiness(OR=4.78,95%CI:1.80,-12.70,P<0.05)and xerostomia(OR=3.07,95%CI:1.31-7.19,P<0.05)were higher than those of the control group.Conclusion:Compared with conventional or placebo therapy,the combined application of 5-HT1A receptor partial agonist therapy can improve the overall efficacy;however,only the incidences of sleepiness and xerostomia are relatively high.
作者
彭彬彬
刘聪
赵梦
赵威
PENG Binbin;LIU Cong;ZHAO Meng;ZHAO Wei(Department of Gastroenterology,Tianjin Medical University General Hospital,Tianjin 300052,China;Department of Medical Imaging,Clinical College of Ningxia Medical University,Yinchuan 750004,China)
出处
《天津医科大学学报》
2025年第1期85-92,共8页
Journal of Tianjin Medical University
基金
国家重点研发计划(2022YFC2504006)。
