摘要
目的探讨胰岛素样生长因子 1(IGF 1)、转化生长因子 (TGF β1 )在高血压左室肥厚(LVH)中的诊断价值。方法选择高血压病 (EH)患者 4 7例 (LVH2 6例、NLVH2 1例 ) ,同步检测其血中IGF 1、TGF β1 、Ⅰ型前胶原羧基端肽 (PICP)、Ⅲ型前胶原氨基端肽 (PⅢNP)水平 ,采用超声心动图仪测定并计算左室重量指数 (LVMI)。并与正常对照组 2 6例进行对比分析。结果EH组血中IGF 1、TGF β1 、PICP、PⅢNP水平均较对照组显著增高 ,以LVH组为甚 ,差异有显著意义 (P <0 0 0 1)。相关分析表明 :IGF 1、TGF β1 分别与PICP、PⅢNP呈正相关 ,IGF 1与TGF β1 呈正相关 ,血中各指标与LVMI亦呈正相关关系。结论IGF 1与TGF β1 在高血压LVH中具有重要作用。
Objective To study the relationship between insulin appearance growth factor 1 (IGF 1), TGF β 1 and left ventricular hypertrophy (LVH) in patients with essential hypertension (EH). Methods IGF 1, TGF β 1 , Collagen carboxyl end peptide (PICP), III-pre-collagen amino end peptide (IIINP) and left ventricular mass index (LVMI) were measured and analysed in 26 normal persons, 21 cases with EH, 26 cases with EH and LVH. Results IGF 1, TGF β 1 and PICP, P IIINP and between LVMI and each blood parameters. Conclusion IGF 1, TGF β 1 play important role in LVH of EH.
出处
《贵州医药》
CAS
2002年第12期1063-1065,共3页
Guizhou Medical Journal
