摘要
目的应用Tei指数评价左室舒张功能变化并探讨其与胶原代谢的血清标志物Ⅰ型前胶原羧基端肽(PICP)、Ⅲ型前胶原氨基端肽(PⅢNP)水平之间的关系。方法将58例E/A<1且EF≥50的原发性高血压或/和冠心病患者分为无心衰组和心衰组,应用超声多普勒方法测定两组的Tei指数,应用ELISA法测定两组的血清PICP、PⅢNP。结果心衰组的Tei指数明显高于无心衰组(P<0.01),并且Tei指数与PICP、PⅢNP显著相关。结论Tei指数具有识别舒张性心力衰竭的特性,结合血清PICP、PⅢNP分析则能间接地反映心肌纤维化的进程。
Objective To study the changes of diastolic function of left ventricle by Tei index and analyse the relations between Tei index and the serum level of C-terminal propeptide of type Ⅰ proeollagen （PⅠCP）, N-terminal propeptide of type Ⅲ procollagen （PⅢNP）. Methods Fifty-eight patients were included in the study ,who have hypertension or/and coronary heart disease ,and match the conditions of F/A〈1 and EF≥50. They were divided into 2 groups by wether have the symptom of congestive hart gailure（CHF）.Tei index were measured and recorded by ultrasound, and The serum concentrations of PICP, PⅢNP were measured by ELISA. Result The Tei index of the group having symptom of CHF was more higher than that of the other group （p 〈0.01）, and There was an correlation between Tel index and the serum PⅠP, PⅢNP level. Conclusion Tel index is useful for diagnosing diastolic heart failure,and to combine two methods of measuring Tei index and serum PⅠCP,PⅢNP level ,the degree of myocardial fibrosis can also be diagnosed.
出处
《上海医学影像》
2007年第2期97-98,共2页
Shanghai Medical Imaging
