摘要
目的 探讨苯甲酸雌二醇对大鼠额部皮质和海马CA1区细胞形态和数量的影响 ,初步研究雌激素对血管性痴呆 (Vas culardementia ,VD)大鼠的神经保护作用。方法 利用双侧颈总动脉持久性结扎及卵巢切除大鼠模型 ,利用光镜、电镜结合图像分析 ,观察大鼠额叶皮质和海马CA1区的病理和超微结构变化。结果 手术组较治疗组大鼠额部皮质和海马CA1区细胞形态改变明显 ,数量减少 ,统计学分析呈显著差异。结论 雌激素具有一定的神经保护作用 。
Objective To study the effects of estradiol benzoate on the morphology and number of neurons in cerebral frontal cortex and hippocampal CA1 area of 2VO OVX rats Methods Eighteen female Wistar rats were randomly divided into 3 groups, that is, sham operation, 2VO OVX (bilateral common carotid artery occlusion and ovariectomy)+ sesame oil, and 2VO OVX+estrogen replacement (named as S, O and E groups respectively) The changes of morphology and number of neurons in frontal cortex and hippocampal CA1 were studied with light and electron microscopy Results The numbers and shape of neurons in frontal cortex and CA1 were well maintained in E group, better than in O group but worse than in S group Significant differences were found in neuron number among 3 groups ( P <0 01) Conclusion Estrogen can exert neuroprotection to some extent, which may be used to ameliorate the symptoms of vascular dementia
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2002年第12期1391-1393,共3页
Journal of Third Military Medical University
基金
国家自然科学基金资助项目 :39770 2 73
