摘要
目的 采用不同物质进行膝关节腔内注射以比较其对骨关节炎关节软骨的影响。方法 6月龄新西兰白兔 12只 ,分实验组和对照组a、b ,实验组采用石膏固定一侧膝关节的方法制作膝骨性关节炎的模型。模型建立后 ,去除固定 ,定期于膝关节腔内注射强的松龙注射液、透明质酸钠、医用氧气、丹参注射液 ,每周 1次 ,共 4次。通过光镜与电镜观察上述物质对骨关节炎关节软骨的影响。对照组a不做任何处理 ,对照组b仅做一侧膝关节固定 ,不行膝关节腔内注射。结果 透明质酸钠对退变的关节软骨有明显的修复作用 ,丹参注射液对关节软骨亦有一定的修复作用。而强的松龙及医用氧气对骨关节炎关节软骨未表现出有益的影响。结论 临床上在治疗骨性关节炎时 。
Objective The purpose of this study was to compare the influences of intraarticular injections of various substances on articular cartilage of knee with osteoarthritis. Methods Twelve rabbits were divided into an experimental ( n =8) and two control (a and b, n =4) groups. Osteoarthritis models were established using the Vandman's technique in all of the 8 rabbits of experimental group and 2 of the control group b, then the delta cortef solution, sodium hyaluronate, medical oxygen, and salvia miltiorrhiza solution were injected, respectively, into the affected knee joints of each two of the 8 rabbits, leaving the 2 rabbits of control group b not injected. Optic and electron microscopic examinations were conducted to observe the pathological changes of articular cartilage of the knee of these animals. Results The results showed that, sodium hyaluronate exhibited beneficial effect on repairment of the involved articular cartilage of the knee with osteoarthritis resulted from long term disuse of the joint. Salvia miltiorrhiza solution also had certain beneficial effects on it, but was not as significant as sodium hyaluronate. Both the delta cortef and medical oxygen exerted no significant beneficial effect in this study. Conclusion Certain therapeutic agents might be helpful, when they are properly selected and used in the form of injection therapy, in the management of osteoarthritis.
出处
《中华物理医学与康复杂志》
CAS
CSCD
北大核心
2002年第2期88-91,共4页
Chinese Journal of Physical Medicine and Rehabilitation
关键词
膝关节腔内注射
骨关节炎
关节软骨
实验研究
Osteoarthritis
Cartilage, articular
Injection, intraarticular
Knee joint
