摘要
目的:观察筋骨片对骨性关节炎(OA)病变发生发展及其修复作用的影响。方法:用石膏绷带制动膝关节的方法给兔造模,给筋骨片药液灌胃治疗。连续给药4周,制动时间满6周时,将各组动物解除制动并停止给药。2周后进行各项指标的测定。结果:筋骨片对模型兔膝关节活动范围有明显的改善作用,各剂量组与模型组比较均有显著性差异;其中、高剂量的Ca/P比值也明显升高;同时筋骨片各剂量组对模型兔膝关节滑膜厚度肿胀有抑制作用,能较好缓解OA的炎性症状,对制动后膝关节内滑膜及软骨的病理变化也有显著的改善作用。筋骨片中、高剂量组还能明显增强滑膜组织SOD的活性,具有清除氧自由基的能力。结论:筋骨片减轻关节软骨的退变,明显抑制滑膜组织的炎症,提高SOD活力使OFR代谢恢复平衡,因而对OA具有一定的治疗效果。
Objective： To observe the influence of Jin Gu Tablet （JGT） on the development and rehabilitation of osteoarthritis （OA）. Methods： The knee joint was fixed with the piaster bandage to make the model of rabbit OA, JGT was orall given for 4 weeks. After brake was applied for 6 weeks, the brake was removed 2 weeks later, measurement of indexes was carried out. Results： JGT can Obviously improve rabbit OA＇s scope of activity of knee joint, Compared with the model group, the middle, high dosage＇s Ca/P ratio obviously rises, every dosage group of JGT can inhitit swelling of thickness of slippery membrane of joint, alleviate the inflammation symptom of OA and obviously improve the pathology changing of slippery membrane and cartilage. The middle, high dosage can also obviously strengthen the activation of SOD of slippery membrane. Condusion： JGT can lighten returning becoming of joint cartilage, obviously inhitit the slippery membrane＇s inflammation and improve SOD activity. The reoults Showed that JGT has effects on OA.
出处
《中国实验方剂学杂志》
CAS
2006年第3期48-51,共4页
Chinese Journal of Experimental Traditional Medical Formulae
