摘要
目的 :探讨血清中文 (GSTs)对非小细胞肺癌的诊断意义及与化疗效的关系。方法 :采用分光光度比色法测定 66例非小细胞肺癌患者血清GSTs、 2 0例肺良性疾病患者及 2 0例健康者作为对照组。结果 :血清GSTs在非小细胞肺癌患者中表达明显高于肺良性病变患者 (P <0 0 1) ,也高于健康者 (P <0 0 1)。 2 6例化疗有效组低于 40例无效组 (P <0 0 5 )。其中 16例患者于化疗前后均行检查 ,GSTs水平无明显差异 (P >0 0 5 )。GSTs与性别、年龄、组织学分型、肿瘤大小、临床分期无明显相关 (P >0 0 5 )。结论 :GSTs可望成为非小细胞肺癌一个诊断指标 。
Objective:To sutdy the relationship of diagnostic value and chemotherapy effect for non-small-cell-lung-cancer with serum GSTs.Methods:Using colorimetric analysis,serum GSTs was tested in 66 cases of non-small-cell-lung-cancer,20 cases of benign lung disease and 20 cases of healthy control.Results:Serum GSTs in non-small-cell-lung-cancer was significantly higher than benign lung disease and healthy control( P <0 01).26 cases with effective chemotherapy were significantly lower than 40 cases with ineffective( P <0 05).There was no marked difference in 16 patients pre-and post-chemotherapy( P >0 05).Serum GSTs was not related to sex,age,tumor size,histological grades and stage( P >0 05).Conclusion:Serum GSTs would possibly become a diagnostic index for non-small-cell-lung-cancer and be able to predict chemotherapy effect.
出处
《武警医学院学报》
CAS
2002年第4期246-248,共3页
Acta Academiae Medicinae CPAPF
