摘要
目的分析依达拉奉与奥扎格雷钠联合用药方案治疗脑梗死的临床效果及对患者NIHSS评分影响。方法选取我院2022年1月至2023年12月期间收治的120例脑梗死患者作为研究对象,遵循随机数字表法分组原则将患者分为参照组(60例)与实验组(60例)。参照组给予奥扎格雷钠治疗,.实验组在参照组基础上联合依达拉奉治疗。观察两.组治疗前后NIHSS评分、氧化.应激指标及疗效。结果.治疗后,.实验组NIHSS评分显著低于参照组(P<005);实验组氧化应激指标改善效果优于参照组(P<005);实验组治疗总有效率9667%高于参照组的8000%(P<005)。结论在脑梗死治疗中,依达拉奉与奥扎格雷钠联合治疗的效果更好,不仅可以更有效的改善患者神经功能,降低机体的氧化应激状态,同时也能提高临床治疗有效性,改善患者预后。
Objective To analyze the clinical effect of edaravone combined with ozagrel sodium in the treatment of cerebral infarction and its influence on NIHSS score.Methods 120 patients with cerebral infarction admitted to our hospital from January 2022 to December 2023 were selected as the research objects,and were divided into the reference group(60 cases)and the experimental group(60 cases)according to the principle of random number table.The reference group was treated with sodium ozagrel,and the experimental group was treated with edaravone based on the reference group.NIHSS score,oxidative stress index and curative effect were observed before and after treatment.Results After treatment,the experimental group NIHSS score significantly lower than that of control group(P<0.05);the improvement of oxidative stress index in experimental group was better than that in reference group(P<0.05).The total effective rate of the experimental group was 96.67%higher than that of the reference group(80.00%)(P<0.05).Conclusion In the treatment of cerebral infarction,Edaravone combined with sodium ozagrel has a better effect,which can not only improve the neurological function of patients more effectively,reduce the oxidative stress state of the body,but also improve the effectiveness of clinical treatment and improve the prognosis of patients.
作者
夏中杰
路雪燕
位霞飞
武帆
张贵艺
程璇
XIA Zhong-jie;LU Xue-yan;WEI Xia-fei;WU Fan;ZHANG Gui-yi;CHENG Xuan(The Second Affiliated Hospital of Xinxiang Medical University,Xinxiang 453002,Henan Province,China;The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China)
出处
《罕少疾病杂志》
2025年第1期23-25,共3页
Journal of Rare and Uncommon Diseases
基金
国家自然科学基金青年科学基金资助项目(81701295)。
关键词
依达拉奉
奥扎格雷钠
脑梗死
NIHSS评分
氧化应激指标
疗效
Edaravone
Sodium Ozagrel
Cerebral Infarction
NIHSS Score
Serum Oxidative Stress Index
Curative Effect
