摘要
目的探讨尤瑞克林联合静脉溶栓治疗急性脑梗死(ACI)患者的具体效果。方法选择2020年2月—2023年7月安丘市人民医院收治的94例ACI患者为研究对象,采用随机数字表法将其分为对照组和观察组,每组47例。对照予以重组组织型纤溶酶原激活剂静脉溶栓治疗,观察组在对照组的基础上加用尤瑞克林治疗。对比两组的临床疗效、血液流变学、血清炎性因子、不良反应。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);治疗后,观察组全血高切粘度、全血低切粘度、血浆粘度的水平均低于对照组,组间差异有统计学意义(P<0.05);观察组降钙素原、C反应蛋白、白细胞介素-8的水平均低于对照组,组间差异有统计学意义(P<0.05);两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论在ACI患者中应用尤瑞克林联合静脉溶栓治疗的效果显著,能够有效改善血液流变学及炎性因子水平,且安全可靠。
Objective To explore the specific effects of the combination of urinary kallidinogenase and intravenous thrombolysis in the treatment of patients with acute cerebral infarction(ACI).Methods 94 ACI patients admitted to Anqiu People's Hospital from February 2020 to July 2023 were selected as the research subjects,divided into a control group and an observation group using a random number table method,with 47 cases in each group.The control group was treated with recombinant tissue plasminogen activator intravenous thrombolysis,while the observation group received additional treatment with urinary kallidinogenase in addition to the control group.Compare the clinical efficacy,hemorheology,serum inflammatory factors,and adverse reactions between two groups.Results The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05);after treatment,the levels of whole blood high shear viscosity,whole blood low shear viscosity,plasma viscosity in the observation group were lower than those in the control group,the difference between groups were statistically significant(P<0.05);the levels of procalcitonin,C-reactive protein,interleukin-8 in the observation group were lower than those in the control group,the differences between groups were statistically significant(P<0.05);comparison of adverse reactions between two groups,the difference was not statistically significant(P>0.05).Conclusion The application of urinary kallidinogenase combined with intravenous thrombolysis in ACI patients has a significant effect,which can effectively improve blood rheology and inflammatory factor levels,and is safe and reliable.
作者
王冠
WANG Guan(Department of Neurology Second Ward,Anqiu People's Hospital,Weifang Shandong,262100,China)
出处
《反射疗法与康复医学》
2024年第7期89-91,95,共4页
Reflexology And Rehabilitation Medicine
关键词
急性脑梗死
尤瑞克林
静脉溶栓
重组组织型纤溶酶原激活剂
血液流变学
血清炎性因子
Acute cerebral infarction
Urinary kallidinogenase
Intravenous thrombolysis
Recombinant tissue plasminogen activator
Hemorheology
Serum inflammatory factors
