摘要
目的 探讨动态容积灌注CT (DVPCT)时间密度曲线(TAC)图像特征及灌注参数与不同病理分级进展期胃癌的相关性。方法 收集经病理证实行DVPCT检查的进展期胃癌患者64例,根据病理结果分为低及高分化组。后处理获得病灶、腹腔干层面腹主动脉及门静脉主干TAC图像特征,比较2组TAC图像特征中病灶峰值期相、峰值时间的差异;测量病灶灌注参数,包括血流量(BF)、血容量(BV)、平均通过时间(MTT)和表面渗透性(PS),比较2组灌注参数的差异。再采用受试者工作特征(ROC)曲线评估相关参数对低分化组胃癌的诊断效能。结果 峰值期相及峰值时间在2组间有显著统计学差异(P<0.05),低分化组峰值期相多在延迟期,高分化组峰值期相多在静脉期。低分化组PS及BV值高于高分化组(P<0.05)。峰值时间、PS、BV诊断低分化组胃癌ROC曲线下面积分别为0.864、0.832及0.667,且峰值时间及PS的诊断效能显著高于BV(P<0.05)。峰值时间、PS分别以32.78s和41.08mL/(100g·min)为界值,诊断低分化组胃癌的敏感度、特异度分别为90.9%、87.5%和81.8%、90.6%。结论 DVPCT TAC图像特征及灌注参数PS、BV有助于进展期胃癌恶性程度的评估。
Objective To explore the correlation between time-attenuation curve(TAC)image features and perfusion parameters of dynamic volume perfusion CT(DVPCT)with different pathological grades of advanced gastric cancer.Methods 64 patients with pathologically confirmed advanced-stage gastric cancer who underwent DVPCT examination were collected.According to pathological results,they were divided into poorly and well-differentiated groups.Post-processing obtained TAC image featu res of the lesions,abdominal aorta at the level of the celiac trunk,and main portal vein,comparing the differences in peak phase and peak time of lesions in the TAC image features between the two groups.Perfusion parameters of the lesions were measured,including blood flow(BF),blood volume(BV),mean transit time(MTT),and permeability surface(PS),and the differences in perfusion parameters between the two groups were compared.receiver operating characteristic(ROC)curves were then used to evaluate the diagnostic efficiency of the relevant parameters for poorly differentiated gastric cancer.Results Peak phase and peak time showed significant statistical differences between the two groups(P<0.05).In the poorly differentiated group,the peak phase was mostly in the delayed phase,while in the well-differentiated group,the peak phase was mostly in the venous phase.The values of PS and BV in poorly differentiated group were higher than those in the well-differentiated group(P<0.05).The diagnostic efficiency of peak time,PS,and BV for poorly differentiated gastric cancer,as indicated by the area under the ROC curve,was 0.864,0.832,and 0.667,respectively.The diagnostic efficiency of peak time and PS was significantly higher than that of BV(P<0.05).Using 32.78s and41.08 mL/(100g·min)as thresholds for peak time and PS,respectively,the sensitivity and specificity for diagnosing poorly differentiated gastric cancer were 90.9%,87.5%and 81.8%,90.6%,respectively.Conclusion DVPCT TAC image features and perfusion parameters(PS and BV)contribute to the assessment of the malignancy of adva nced-stage gastric cancer.
作者
彭金成
明兵
张仕勇
邹庆
兰茜琳
俞溪
刘婷
PENG Jin-cheng;MING Bing;ZHANG Shi-yong;ZOU Qing;LAN Xi-lin;YU Xi;LIU Ting(School of Medical Imaging,North Sichuan Medical College,Nanchong 637000,Sichuan Province,China;Department of Radiology,Deyang People's Hospital,Deyang 618000,Sichuan Province,China)
出处
《中国CT和MRI杂志》
2025年第1期153-155,共3页
Chinese Journal of CT and MRI
基金
德阳市科技计划项目(2022SCZ139)。
关键词
胃癌
体层摄影术
灌注成像
Gastric Cancer
Tomography
Perfusion Imaging
