摘要
EB病毒(Epstein-Barr virus,EBV)作为最早被发现的致癌病毒,与鼻咽癌、胃癌、淋巴瘤的发病密切相关.尽管EB病毒自1964年被发现至今已经被研究了60年,但其原发感染、慢性感染和再激活所导致的多种重症非肿瘤性疾病、恶性肿瘤及自身免疫性疾病相关机制远未阐明.本文综述了EBV抗体对于EBV相关疾病的辅助诊断、临床应用及研究进展,并讨论了各类EBV相关疾病的特点及早期诊断面临的挑战,旨在对EBV抗体的规范应用提供理论支持,帮助明确EBV抗体的研究方向和应用前景.
Epstein-Barr virus(EBV),as the earliest discovered oncogenic virus,is closely related to the pathogenesis of nasopharyngeal carcinoma,gastric cancer and lymphoma.Although EBV has been studied for 60 years since its discovery in 1964,the mechanism of primary infection,chronic infection and reactivation caused by a variety of severe non-neoplastic diseases,malignant tumors and autoimmune diseases is far from clear.In this review,we summarize the clinical application and research progress of EBV antibodies in EBV-related diseases,and discuss the characteristics of various EBV-related diseases and the challenges of early diagnosis.The main point is to provide theoretical support for the standardized application of EBV antibodies and to help clarify the research directions and application prospects of EBV antibodies.
作者
张奥
刘万里
曾木圣
ZHANG Ao;LIU WanLi;ZENG Mu-Sheng(State Key Laboratory of Oncology in South China,Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy,Guangdong Provincial Clinical Research Center for Cancer,Sun Yat-sen University Cancer Center,Guangzhou 510060,China)
出处
《中国科学:生命科学》
CSCD
北大核心
2024年第12期2399-2407,共9页
Scientia Sinica(Vitae)
基金
国家重点研发计划(批准号:2022YFC3400900)
创新研究群体项目(批准号:82321003)资助。
